Ankyrin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:12, 21 March 2021) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='1n11' size='450' side='right' scene='45/454440/Cv/1' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]'>
+
<StructureSection load='1n11' size='350' side='right' scene='45/454440/Cv/1' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]'>
Line 16: Line 16:
*'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br />
*'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br />
-
'''Gankyrin''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats.
+
'''Gankyrin''' or '''26S proteasome non-ATPase regulatory subunit 10''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats.
== Disease ==
== Disease ==
Line 28: Line 28:
== Structural highlights ==
== Structural highlights ==
-
Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>.
+
Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>
-
== 3D Structures of Ankyrin ==
+
== 3D Structures of ankyrin ==
 +
[[Ankyrin 3D structures]]
 +
 +
</StructureSection>
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
== References ==
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
<references/>
-
 
+
-
*Ankyrin
+
-
 
+
-
**[[1n11]] – hANK-1 D34 region – human<br />
+
-
**[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br />
+
-
**[[3f59]] – hANK-1 spectrin-binding domain<br />
+
-
**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br />
+
-
**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />
+
-
**[[4o6x]] - hANK-3 death domain<br />
+
-
**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
+
-
**[[4rlv]] - hANK-1 + hANK-2<br />
+
-
**[[3so8]] – hANK-A residues 149-310<br />
+
-
**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
+
-
**[[1svx]] – dANK + maltose-binding protein<br />
+
-
**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
+
-
**[[2aja]] – ANK – Legionella pneumophila<br />
+
-
**[[3hra]] – ANK – Enterococus faecalis<br />
+
-
**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
+
-
 
+
-
*Gankyrin
+
-
 
+
-
**[[1uoh]], [[1qym]] – hGANK<br />
+
-
**[[1tr4]] – hGANK – NMR<br />
+
-
**[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse
+
-
}}
+
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions 1n11

Drag the structure with the mouse to rotate

References

  1. ↑ Michaely P, Tomchick DR, Machius M, Anderson RG. Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646
  2. ↑ Mosavi LK, Minor DL Jr, Peng ZY. Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16029-34. Epub 2002 Dec 2. PMID:12461176 doi:http://dx.doi.org/10.1073/pnas.252537899

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Narendra Kumar Verma

Retrieved from "http://52.214.119.220/wiki/index.php/Ankyrin"
Personal tools