1dzi

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[[Image:1dzi.gif|left|200px]]
[[Image:1dzi.gif|left|200px]]
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{{Structure
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|PDB= 1dzi |SIZE=350|CAPTION= <scene name='initialview01'>1dzi</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1dzi", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>
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{{STRUCTURE_1dzi| PDB=1dzi | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzi OCA], [http://www.ebi.ac.uk/pdbsum/1dzi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dzi RCSB]</span>
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}}
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'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''
'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''
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[[Category: Knight, G.]]
[[Category: Knight, G.]]
[[Category: Liddington, R.]]
[[Category: Liddington, R.]]
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[[Category: collagen]]
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[[Category: Collagen]]
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[[Category: integrin]]
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[[Category: Integrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:28:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:51:53 2008''
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Revision as of 11:28, 2 May 2008

Image:1dzi.gif

Template:STRUCTURE 1dzi

INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX


Overview

We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.

About this Structure

1DZI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:10778855 Page seeded by OCA on Fri May 2 14:28:26 2008

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