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2hqq
From Proteopedia
(Difference between revisions)
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==Crystal structure of human ketohexokinase complexed to different sugar molecules== | ==Crystal structure of human ketohexokinase complexed to different sugar molecules== | ||
| - | <StructureSection load='2hqq' size='340' side='right' caption='[[2hqq]], [[Resolution|resolution]] 1.86Å' scene=''> | + | <StructureSection load='2hqq' size='340' side='right'caption='[[2hqq]], [[Resolution|resolution]] 1.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2hqq]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2hqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQQ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHK ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ketohexokinase Ketohexokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.3 2.7.1.3] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqq OCA], [https://pdbe.org/2hqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqq RCSB], [https://www.ebi.ac.uk/pdbsum/2hqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqq ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN]] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Ketohexokinase]] | [[Category: Ketohexokinase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Asipu, A]] | [[Category: Asipu, A]] | ||
[[Category: Bonthron, D T]] | [[Category: Bonthron, D T]] | ||
Revision as of 07:19, 24 March 2021
Crystal structure of human ketohexokinase complexed to different sugar molecules
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