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2hxr

From Proteopedia

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[[Image:2hxr.gif|left|200px]]
 
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{{Structure
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==Structure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolism==
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|PDB= 2hxr |SIZE=350|CAPTION= <scene name='initialview01'>2hxr</scene>, resolution 2.05&Aring;
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<StructureSection load='2hxr' size='340' side='right'caption='[[2hxr]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2hxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXR FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|GENE= cynR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1utb|1utb]], [[1uth|1uth]], [[1al3|1al3]]</div></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03466 LysR_substrate]</span>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cynR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxr OCA], [http://www.ebi.ac.uk/pdbsum/2hxr PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2hxr RCSB]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxr OCA], [https://pdbe.org/2hxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxr RCSB], [https://www.ebi.ac.uk/pdbsum/2hxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxr ProSAT], [https://www.topsan.org/Proteins/MCSG/2hxr TOPSAN]</span></td></tr>
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}}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CYNR_ECOLI CYNR_ECOLI]] Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxr ConSurf].
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<div style="clear:both"></div>
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'''Structure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolism'''
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2HXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXR OCA].
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[[Category: Ecoli]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cuff, M E]]
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[[Category: Cuff, M E.]]
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[[Category: Edwards, A M]]
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[[Category: Edwards, A M.]]
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[[Category: Evdokimova, E]]
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[[Category: Evdokimova, E.]]
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[[Category: Joachimiak, A]]
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[[Category: Joachimiak, A.]]
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[[Category: Kagan, O]]
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[[Category: Kagan, O.]]
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[[Category: Structural genomic]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Savchenko, A]]
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[[Category: Savchenko, A.]]
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[[Category: Singer, A U]]
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[[Category: Singer, A U.]]
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[[Category: Cynr transcriptional regulator lysr crystal structure]]
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[[Category: cynr transcriptional regulator lysr crystal structure]]
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[[Category: Mcsg]]
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[[Category: mcsg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: midwest center for structural genomic]]
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[[Category: Transcription]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:30:09 2008''
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Current revision

Structure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolism

PDB ID 2hxr

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