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2i5t

From Proteopedia

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[[Image:2i5t.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of hypothetical protein LOC79017 from Homo sapiens==
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|PDB= 2i5t |SIZE=350|CAPTION= <scene name='initialview01'>2i5t</scene>, resolution 2.01&Aring;
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<StructureSection load='2i5t' size='340' side='right'caption='[[2i5t]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[2i5t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I5T FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|GENE= C7orf24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C7orf24 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06094 AIG2]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i5t OCA], [https://pdbe.org/2i5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i5t RCSB], [https://www.ebi.ac.uk/pdbsum/2i5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i5t ProSAT], [https://www.topsan.org/Proteins/CESG/2i5t TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i5t OCA], [http://www.ebi.ac.uk/pdbsum/2i5t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i5t RCSB]</span>
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== Function ==
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}}
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[[https://www.uniprot.org/uniprot/GGCT_HUMAN GGCT_HUMAN]] Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.<ref>PMID:16765912</ref> <ref>PMID:18515354</ref>
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== Evolutionary Conservation ==
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'''Crystal Structure of hypothetical protein LOC79017 from Homo sapiens'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/2i5t_consurf.spt"</scriptWhenChecked>
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2I5T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5T OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of Homo sapiens protein LOC79017., Bae E, Bingman CA, Aceti DJ, Phillips GN Jr, Proteins. 2008 Feb 1;70(2):588-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932939 17932939]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i5t ConSurf].
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[[Category: Homo sapiens]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Bae, E.]]
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<references/>
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[[Category: Bingman, C A.]]
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__TOC__
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[[Category: Bitto, E.]]
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</StructureSection>
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Human]]
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[[Category: Jr, G N.Phillips.]]
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[[Category: Large Structures]]
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[[Category: Wesenberg, G E.]]
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[[Category: Bae, E]]
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[[Category: center for eukaryotic structural genomic]]
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[[Category: Bingman, C A]]
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[[Category: cesg]]
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[[Category: Bitto, E]]
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[[Category: protein structure initiative]]
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[[Category: Structural genomic]]
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[[Category: psi-2]]
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[[Category: Phillips, G N]]
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[[Category: structural genomic]]
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[[Category: Wesenberg, G E]]
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[[Category: unknown function]]
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[[Category: Cesg]]
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[[Category: PSI, Protein structure initiative]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:07 2008''
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[[Category: Unknown function]]

Current revision

Crystal Structure of hypothetical protein LOC79017 from Homo sapiens

PDB ID 2i5t

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OCA

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