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2i6e

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[[Image:2i6e.gif|left|200px]]
 
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==Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178==
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The line below this paragraph, containing "STRUCTURE_2i6e", creates the "Structure Box" on the page.
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<StructureSection load='2i6e' size='340' side='right'caption='[[2i6e]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I6E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6e OCA], [https://pdbe.org/2i6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i6e RCSB], [https://www.ebi.ac.uk/pdbsum/2i6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i6e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i6e TOPSAN]</span></td></tr>
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-->
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</table>
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{{STRUCTURE_2i6e| PDB=2i6e | SCENE= }}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i6e_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i6e ConSurf].
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2I6E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17908300 17908300]
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[[Category: Large Structures]]
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[[Category: Deinococcus radiodurans]]
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[[Category: Burley SK]]
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[[Category: Single protein]]
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[[Category: Kumaran D]]
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[[Category: Burley, S K.]]
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[[Category: Swaminathan S]]
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[[Category: Kumaran, D.]]
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[[Category: Tyagi R]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Swaminathan, S.]]
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[[Category: Tyagi, R.]]
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[[Category: Hypothetical protein,pfam:duf178]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nysgxrc,10093b]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:07:58 2008''
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Current revision

Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178

PDB ID 2i6e

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