User:Hannah Wright/Sandbox 1
From Proteopedia
(Difference between revisions)
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===Significance=== | ===Significance=== | ||
| + | ===General Function=== | ||
<scene name='87/877603/Lplwcolors/1'>Birrane et. al.</scene> | <scene name='87/877603/Lplwcolors/1'>Birrane et. al.</scene> | ||
<ref name="Birrane">PMID:30559189</ref> | <ref name="Birrane">PMID:30559189</ref> | ||
| - | == | + | == Structure == |
| - | === | + | ===Overall Structure=== |
| - | + | ===LPL=== | |
| - | === | + | ====N-terminus of LPL==== |
| - | + | =====Calcium Ion Coordination===== | |
| + | ====C-terminus of LPL==== | ||
| + | =====GPIHBP1===== | ||
===Active Site=== | ===Active Site=== | ||
<scene name='87/877603/Catalytic_triad/1'>Catalytic Triad</scene> | <scene name='87/877603/Catalytic_triad/1'>Catalytic Triad</scene> | ||
| + | ====Mechanism==== | ||
| + | </StructureSection> | ||
| + | |||
== Disease == | == Disease == | ||
===Mutations=== | ===Mutations=== | ||
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===Hypertriglycerademia=== | ===Hypertriglycerademia=== | ||
===Drug Relevance=== | ===Drug Relevance=== | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
Revision as of 18:59, 30 March 2021
Contents |
Lipoprotein Lipase (LPL) complexed with GPIHBP1
| |||||||||||
Disease
Mutations
D201V
M404R
Relevance
Hypertriglycerademia
Drug Relevance
</StructureSection>
References
- ↑ Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 1817984116. doi:, 10.1073/pnas.1817984116. PMID:30559189 doi:http://dx.doi.org/10.1073/pnas.1817984116
Student/Contributors
- Ashrey Burely
- Allison Welz
- Hannah Wright
