1e12

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[[Image:1e12.gif|left|200px]]
[[Image:1e12.gif|left|200px]]
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{{Structure
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|PDB= 1e12 |SIZE=350|CAPTION= <scene name='initialview01'>1e12</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1e12", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPG:1-MONOOLEOYL-RAC-GLYCEROL'>MPG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>
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|DOMAIN=
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{{STRUCTURE_1e12| PDB=1e12 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e12 OCA], [http://www.ebi.ac.uk/pdbsum/1e12 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e12 RCSB]</span>
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'''HALORHODOPSIN, A LIGHT-DRIVEN CHLORIDE PUMP'''
'''HALORHODOPSIN, A LIGHT-DRIVEN CHLORIDE PUMP'''
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[[Category: Kolbe, M.]]
[[Category: Kolbe, M.]]
[[Category: Oesterhelt, D.]]
[[Category: Oesterhelt, D.]]
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[[Category: chloride pump]]
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[[Category: Chloride pump]]
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[[Category: chloride transport]]
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[[Category: Chloride transport]]
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[[Category: haloarchaea]]
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[[Category: Haloarchaea]]
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[[Category: ion pump]]
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[[Category: Ion pump]]
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[[Category: lipid]]
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[[Category: Lipid]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: palmitate]]
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[[Category: Palmitate]]
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[[Category: retinal protein]]
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[[Category: Retinal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:31:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:52:51 2008''
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Revision as of 11:31, 2 May 2008

Image:1e12.gif

Template:STRUCTURE 1e12

HALORHODOPSIN, A LIGHT-DRIVEN CHLORIDE PUMP


Overview

Halorhodopsin, an archaeal rhodopsin ubiquitous in Haloarchaea, uses light energy to pump chloride through biological membranes. Halorhodopsin crystals were grown in a cubic lipidic phase, which allowed the x-ray structure determination of this anion pump at 1.8 angstrom resolution. Halorhodopsin assembles to trimers around a central patch consisting of palmitic acid. Next to the protonated Schiff base between Lys(242) and the isomerizable retinal chromophore, a single chloride ion occupies the transport site. Energetic calculations on chloride binding reveal a combination of ion-ion and ion-dipole interactions for stabilizing the anion 18 angstroms below the membrane surface. Ion dragging across the protonated Schiff base explains why chloride and proton translocation modes are mechanistically equivalent in archaeal rhodopsins.

About this Structure

1E12 is a Single protein structure of sequence from Halobacterium salinarum. The following page contains interesting information on the relation of 1E12 with [Bacteriorhodopsin]. Full crystallographic information is available from OCA.

Reference

Structure of the light-driven chloride pump halorhodopsin at 1.8 A resolution., Kolbe M, Besir H, Essen LO, Oesterhelt D, Science. 2000 May 26;288(5470):1390-6. PMID:10827943 Page seeded by OCA on Fri May 2 14:31:42 2008

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