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2if7

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(New page: 200px<br /> <applet load="2if7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2if7, resolution 3.000&Aring;" /> '''Crystal Structure ...)
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[[Image:2if7.gif|left|200px]]<br />
 
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<applet load="2if7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2if7, resolution 3.000&Aring;" />
 
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'''Crystal Structure of NTB-A'''<br />
 
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==Overview==
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==Crystal Structure of NTB-A==
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The signaling lymphocytic activation molecule (SLAM) family includes, homophilic and heterophilic receptors that regulate both innate and, adaptive immunity. The ectodomains of most SLAM family members are, composed of an N-terminal IgV domain and a C-terminal IgC2 domain., NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates, cytotoxicity in natural killer (NK) cells, regulates bactericidal, activities in neutrophils, and potentiates T helper 2 (Th2) responses. The, 3.0 A crystal structure of the complete NTB-A ectodomain revealed a, rod-like monomer that self-associates to form a highly kinked dimer, spanning an end-to-end distance of approximately 100 A. The NTB-A, homophilic and CD2-CD58 heterophilic dimers show overall structural, similarities but differ in detailed organization and physicochemical, properties of their respective interfaces. The NTB-A structure suggests a, mechanism responsible for binding specificity within the SLAM family and, imposes physical constraints relevant to the colocalization of SLAM-family, proteins with other signaling molecules in the immunological synapse.
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<StructureSection load='2if7' size='340' side='right'caption='[[2if7]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2if7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IF7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLAMF6, KALI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2if7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if7 OCA], [https://pdbe.org/2if7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2if7 RCSB], [https://www.ebi.ac.uk/pdbsum/2if7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2if7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SLAF6_HUMAN SLAF6_HUMAN]] Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.<ref>PMID:11489943</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2if7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2if7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and adaptive immunity. The ectodomains of most SLAM family members are composed of an N-terminal IgV domain and a C-terminal IgC2 domain. NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities but differ in detailed organization and physicochemical properties of their respective interfaces. The NTB-A structure suggests a mechanism responsible for binding specificity within the SLAM family and imposes physical constraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in the immunological synapse.
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==About this Structure==
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NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family.,Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC Immunity. 2006 Oct;25(4):559-70. PMID:17045824<ref>PMID:17045824</ref>
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2IF7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IF7 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family., Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC, Immunity. 2006 Oct;25(4):559-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17045824 17045824]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 2if7" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Almo, S.C.]]
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<references/>
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[[Category: Cao, E.]]
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__TOC__
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[[Category: Fedorov, A.A.]]
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</StructureSection>
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[[Category: Fedorov, E.V.]]
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[[Category: Human]]
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[[Category: Nathenson, S.G.]]
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[[Category: Large Structures]]
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[[Category: Ramagopal, U.A.]]
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[[Category: Almo, S C]]
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[[Category: CA]]
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[[Category: Cao, E]]
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[[Category: CL]]
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[[Category: Fedorov, A A]]
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[[Category: homophilic receptor]]
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[[Category: Fedorov, E V]]
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[[Category: ly108]]
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[[Category: Nathenson, S G]]
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[[Category: ntb-a]]
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[[Category: Ramagopal, U A]]
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[[Category: slam6]]
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[[Category: Homophilic receptor]]
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[[Category: Immune system]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:44:08 2007''
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[[Category: Ly108]]
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[[Category: Ntb-a]]
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[[Category: Slam6]]

Current revision

Crystal Structure of NTB-A

PDB ID 2if7

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