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2ija
From Proteopedia
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| - | [[Image:2ija.png|left|200px]] | ||
| - | + | ==Human N-acetyltransferase 1 F125S mutant== | |
| - | + | <StructureSection load='2ija' size='340' side='right'caption='[[2ija]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ija]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IJA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[2ija]] is a 1 chain structure | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAT1, AAC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ija FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ija OCA], [https://pdbe.org/2ija PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ija RCSB], [https://www.ebi.ac.uk/pdbsum/2ija PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ija ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ARY1_HUMAN ARY1_HUMAN]] Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/2ija_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ija ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Arylamine N-acetyltransferase|Arylamine N-acetyltransferase]] | + | *[[Arylamine N-acetyltransferase 3D structures|Arylamine N-acetyltransferase 3D structures]] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Arylamine N-acetyltransferase]] | [[Category: Arylamine N-acetyltransferase]] | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Large Structures]] |
| - | [[Category: Bochkarev, A | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Dombrovski, L | + | [[Category: Bochkarev, A]] |
| - | [[Category: Edwards, A M | + | [[Category: Dombrovski, L]] |
| - | [[Category: Grant, D M | + | [[Category: Edwards, A M]] |
| - | [[Category: Loppnau, P | + | [[Category: Grant, D M]] |
| - | [[Category: Plotnikov, A N | + | [[Category: Loppnau, P]] |
| - | [[Category: | + | [[Category: Plotnikov, A N]] |
| - | [[Category: Sundstrom, M | + | [[Category: Structural genomic]] |
| - | [[Category: Tempel, W | + | [[Category: Sundstrom, M]] |
| - | [[Category: Weigelt, J | + | [[Category: Tempel, W]] |
| - | [[Category: Wu, H | + | [[Category: Weigelt, J]] |
| + | [[Category: Wu, H]] | ||
[[Category: Arylamide acetylase 1]] | [[Category: Arylamide acetylase 1]] | ||
[[Category: Arylamine n-acetyltransferase 1]] | [[Category: Arylamine n-acetyltransferase 1]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Current revision
Human N-acetyltransferase 1 F125S mutant
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Categories: Arylamine N-acetyltransferase | Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Dombrovski, L | Edwards, A M | Grant, D M | Loppnau, P | Plotnikov, A N | Structural genomic | Sundstrom, M | Tempel, W | Weigelt, J | Wu, H | Arylamide acetylase 1 | Arylamine n-acetyltransferase 1 | Sgc | Transferase
