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2jhk
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2jhk' size='340' side='right' caption='[[2jhk]], [[Resolution|resolution]] 1.75Å' scene=''> | + | ==Structure of globular heads of M-ficolin complexed with N-acetyl-D- glucosamine== |
| + | <StructureSection load='2jhk' size='340' side='right'caption='[[2jhk]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jhk]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2jhk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHK FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jhh|2jhh]], [[2jhi|2jhi]], [[2jhl|2jhl]], [[2jhm|2jhm]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jhh|2jhh]], [[2jhi|2jhi]], [[2jhl|2jhl]], [[2jhm|2jhm]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhk OCA], [https://pdbe.org/2jhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhk RCSB], [https://www.ebi.ac.uk/pdbsum/2jhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhk ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/FCN1_HUMAN FCN1_HUMAN]] Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.<ref>PMID:20032467</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhk_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhk_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhk ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2jhk" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Arlaud, G J | + | [[Category: Large Structures]] |
| - | [[Category: Gaboriaud, C | + | [[Category: Arlaud, G J]] |
| - | [[Category: Garlatti, V | + | [[Category: Gaboriaud, C]] |
| - | [[Category: Gout, E | + | [[Category: Garlatti, V]] |
| - | [[Category: Martin, L | + | [[Category: Gout, E]] |
| - | [[Category: Reiser, J B | + | [[Category: Martin, L]] |
| - | [[Category: Thielens, N M | + | [[Category: Reiser, J B]] |
| + | [[Category: Thielens, N M]] | ||
[[Category: Acidic ph]] | [[Category: Acidic ph]] | ||
[[Category: Collagen]] | [[Category: Collagen]] | ||
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[[Category: Innate immunity]] | [[Category: Innate immunity]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
| + | [[Category: Polymorphism]] | ||
| + | [[Category: Sugar binding protein]] | ||
[[Category: Sugar-binding protein]] | [[Category: Sugar-binding protein]] | ||
Current revision
Structure of globular heads of M-ficolin complexed with N-acetyl-D- glucosamine
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