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2jv0

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{{Seed}}
 
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[[Image:2jv0.png|left|200px]]
 
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<!--
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==SET domain of RIZ1 tumor suppressor (PRDM2)==
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The line below this paragraph, containing "STRUCTURE_2jv0", creates the "Structure Box" on the page.
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<StructureSection load='2jv0' size='340' side='right'caption='[[2jv0]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JV0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene></td></tr>
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-->
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qpw|2qpw]]</div></td></tr>
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{{STRUCTURE_2jv0| PDB=2jv0 | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDM2, RIZ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jv0 OCA], [https://pdbe.org/2jv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jv0 RCSB], [https://www.ebi.ac.uk/pdbsum/2jv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jv0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/PRDM2_HUMAN PRDM2_HUMAN]] S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.<ref>PMID:14633678</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/2jv0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jv0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RIZ1 is a transcriptional regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3. It contains a distinct SET domain, sometimes referred to as PR (PRDI-BF1 and RIZ1 homology) domain, that is responsible for its catalytic activity. We determined the solution structure of the PR domain from RIZ1 and characterized its interaction with S-adenosyl-l-homocysteine (SAH) and a peptide from histone H3. Despite low sequence identity with canonical SET domains, the PR domain displays a typical SET fold including a pseudo-knot at the C-terminus. The N-flanking sequence of RIZ1 PR domain adopts a novel conformation and interacts closely with the SET fold. The C-flanking sequence contains an alpha-helix that points away from the protein face that harbors active site in other SET domains. The SET fold of RIZ1 does not have detectable affinity for SAH but it interacts with a synthetic peptide comprising residues 1-20 of histone H3.
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===SET domain of RIZ1 tumor suppressor (PRDM2)===
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Structural studies of the SET domain from RIZ1 tumor suppressor.,Briknarova K, Zhou X, Satterthwait A, Hoyt DW, Ely KR, Huang S Biochem Biophys Res Commun. 2008 Feb 15;366(3):807-13. Epub 2007 Dec 17. PMID:18082620<ref>PMID:18082620</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18082620}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jv0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18082620 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_18082620}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human]]
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2JV0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV0 OCA].
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[[Category: Large Structures]]
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[[Category: Briknarova, K]]
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==Reference==
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<ref group="xtra">PMID:18082620</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Briknarova, K.]]
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[[Category: Activator]]
[[Category: Activator]]
[[Category: Alternative initiation]]
[[Category: Alternative initiation]]
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[[Category: Alternative splicing]]
 
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Histone lysine methyltransferase]]
[[Category: Histone lysine methyltransferase]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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[[Category: Zinc]]
 
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:48:09 2009''
 

Current revision

SET domain of RIZ1 tumor suppressor (PRDM2)

PDB ID 2jv0

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