1e4e

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[[Image:1e4e.jpg|left|200px]]
[[Image:1e4e.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1e4e |SIZE=350|CAPTION= <scene name='initialview01'>1e4e</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1e4e", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Phy+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Phy+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Adp+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Adp+Binding+Site+For+Chain+B'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PHY:1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC+ACID'>PHY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= VANA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 Enterococcus faecium])
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-->
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|DOMAIN=
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{{STRUCTURE_1e4e| PDB=1e4e | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e4e OCA], [http://www.ebi.ac.uk/pdbsum/1e4e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e4e RCSB]</span>
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}}
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'''D-ALANYL-D-LACATE LIGASE'''
'''D-ALANYL-D-LACATE LIGASE'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Roper, D I.]]
[[Category: Roper, D I.]]
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[[Category: antibiotic resistance]]
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[[Category: Antibiotic resistance]]
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[[Category: cell wall]]
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[[Category: Cell wall]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: peptidoglycan synthesis]]
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[[Category: Peptidoglycan synthesis]]
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[[Category: plasmid]]
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[[Category: Plasmid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:38:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:54:54 2008''
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Revision as of 11:38, 2 May 2008

Image:1e4e.jpg

Template:STRUCTURE 1e4e

D-ALANYL-D-LACATE LIGASE


Overview

d-alanine-d-lactate ligase from Enterococcus faecium BM4147 is directly responsible for the biosynthesis of alternate cell-wall precursors in bacteria, which are resistant to the glycopeptide antibiotic vancomycin. The crystal structure has been determined with data extending to 2.5-A resolution. This structure shows that the active site has unexpected interactions and is distinct from previous models for d-alanyl-d-lactate ligase mechanistic studies. It appears that the preference of the enzyme for lactate as a ligand over d-alanine could be mediated by electrostatic effects and/or a hydrogen-bonding network, which principally involve His-244. The structure of d-alanyl-d-lactate ligase provides a revised interpretation of the molecular events that lead to vancomycin resistance.

About this Structure

1E4E is a Protein complex structure of sequences from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA)., Roper DI, Huyton T, Vagin A, Dodson G, Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8921-5. PMID:10908650 Page seeded by OCA on Fri May 2 14:38:55 2008

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OCA

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