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2kcx

From Proteopedia

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{{Seed}}
 
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[[Image:2kcx.png|left|200px]]
 
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==Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.==
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The line below this paragraph, containing "STRUCTURE_2kcx", creates the "Structure Box" on the page.
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<StructureSection load='2kcx' size='340' side='right'caption='[[2kcx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KCX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FSTL3, FLRG, UNQ674/PRO1308 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcx OCA], [https://pdbe.org/2kcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kcx RCSB], [https://www.ebi.ac.uk/pdbsum/2kcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcx ProSAT], [https://www.topsan.org/Proteins/NESGC/2kcx TOPSAN]</span></td></tr>
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{{STRUCTURE_2kcx| PDB=2kcx | SCENE= }}
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
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== Function ==
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[[https://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.<ref>PMID:11948405</ref> <ref>PMID:15451575</ref> <ref>PMID:15574124</ref> <ref>PMID:16336961</ref> <ref>PMID:17868029</ref> <ref>PMID:17878677</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/2kcx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kcx ConSurf].
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<div style="clear:both"></div>
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===Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.===
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==See Also==
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*[[Follistatin|Follistatin]]
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== References ==
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==About this Structure==
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<references/>
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2KCX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCX OCA].
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__TOC__
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[[Category: Homo sapiens]]
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</StructureSection>
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[[Category: Anderson, S.]]
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[[Category: Human]]
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[[Category: Chiang, Y.]]
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[[Category: Large Structures]]
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[[Category: Montelione, G T.]]
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[[Category: Anderson, S]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Chiang, Y]]
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[[Category: Rossi, P.]]
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[[Category: Montelione, G T]]
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[[Category: Structural genomic]]
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[[Category: Rossi, P]]
[[Category: Chromosomal rearrangement]]
[[Category: Chromosomal rearrangement]]
[[Category: Follistatin]]
[[Category: Follistatin]]
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[[Category: Kazal-1]]
[[Category: Kazal-1]]
[[Category: Nesg]]
[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
 
[[Category: Nucleotide-binding protein]]
[[Category: Nucleotide-binding protein]]
[[Category: Nucleus]]
[[Category: Nucleus]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
[[Category: Proto-oncogene]]
[[Category: Proto-oncogene]]
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[[Category: Psi-2]]
 
[[Category: Secreted]]
[[Category: Secreted]]
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[[Category: Solution nmr]]
 
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[[Category: Structural genomic]]
 
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 12:50:33 2009''
 

Current revision

Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.

PDB ID 2kcx

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