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2kjx
From Proteopedia
(Difference between revisions)
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==Solution structure of the extracellular domain of JTB== | ==Solution structure of the extracellular domain of JTB== | ||
| - | <StructureSection load='2kjx' size='340' side='right' caption='[[2kjx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kjx' size='340' side='right'caption='[[2kjx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kjx]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJX FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JTB ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JTB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kjx OCA], [https://pdbe.org/2kjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kjx RCSB], [https://www.ebi.ac.uk/pdbsum/2kjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kjx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/JTB_HUMAN JTB_HUMAN]] Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).<ref>PMID:21225229</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Bazan, F]] | [[Category: Bazan, F]] | ||
[[Category: Fairbrother, W J]] | [[Category: Fairbrother, W J]] | ||
Current revision
Solution structure of the extracellular domain of JTB
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