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Sandbox Reserved 1665

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Revision as of 16:54, 16 April 2021

This Sandbox is Reserved from 01/25/2021 through 04/30/2021 for use in Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1665 through Sandbox Reserved 1682.

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Click the edit this page tab at the top. Save the page after each step, then edit it again.
show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
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More help: Help:Editing

Structure of Aldehyde Dehydrogenase C (AldC) mutant (C291A) from Pseudomonas syringae in complexed with NAD+ and Octanal

This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

1 Function of your protein
2 Biological relevance and broader implications
3 Important amino acids
4 Structural highlights
5 Other important features

Function of your protein

The protein in the article is Aldehyde dehydrogenase (AldC) and It has many functions. It helps with detoxification of aldehydes which are highly reactive compounds that are generated through cellular metabolism. It is also involved in biochemical functions from ethanol metabolism through oxidations, polyamine metabolism, and protective cellular response to stresses.

The organism the protein is from is Pseudomonas syringae pv.tomatoe (PtoDC3000).

Biological relevance and broader implications

This can be relevant to certain famers growing crops in different environments or climates. Pseudomonas syringae is a pathogen that can attack a wide variety of woody plant, it especially attacks them when the plants have been damaged by frost or an injury. Knowing this information farmers can be prepared so their crops are not affected by this pathogen. They can use a certain type of spray/chemical to protect them from it.

Important amino acids

4 Catalytic Residues (blue color)

Asn 159, Glu 257, Gly 288, Cys 291

(binding site, 19 residues)

Ile 155, Asn 159, Lys 182, Gly 219, Ile 233-Ser 236, Ala 239, Leu 242, Glu 257, Leu 258, Gly 259, Cys 291, Glu 391, Phe 393

Trp 160, Tyr 163, Trp 450, Phe 456, Tyr 458, Met 114, Leu 118

Structural highlights

Secondary structure has feature and domains, the N-terminus of the protein contains a central Beta sheet that is surrounded by alpha helices to form the NAD(H)-binding site. Around the C-Terminus end of the protein it consists a mix of alpha/beta domains, which include a catalytic cysteine residue and forms the aldehyde -binding site. The article mentions as well what connects the N and C terminal domains of the protein AldC is by an interdomain linker region.

Other important features

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

^[1]

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1665"

@@ Line 23: / Line 23: @@
 :Ile 155, Asn 159, Lys 182, Gly 219, Ile 233-Ser 236, Ala 239, Leu 242, Glu 257, Leu 258, Gly 259, Cys 291, Glu 391, Phe 393
-'''<scene name='87/873227/Octanol_ligand/1'>Octanal Ligand</scene>''' (binding site)
+'''<scene name='87/873227/Octanol_ligand/1'>Octanal Ligand</scene>''' <scene name='87/873227/Octanal-binding_site/1'>(binding site)</scene>
 :Trp 160, Tyr 163, Trp 450, Phe 456, Tyr 458, Met 114, Leu 118

Sandbox Reserved 1665

From Proteopedia

Revision as of 16:54, 16 April 2021

Structure of Aldehyde Dehydrogenase C (AldC) mutant (C291A) from Pseudomonas syringae in complexed with NAD+ and Octanal

Contents

Function of your protein

Biological relevance and broader implications

Important amino acids

Structural highlights

Other important features

References

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