1e7z

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[[Image:1e7z.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1e7z", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=HG1:Hg+Binding+Site+For+Residue+500+A'>HG1</scene> and <scene name='pdbsite=HG2:Hg+Binding+Site+For+Residue+501+A'>HG2</scene>
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{{STRUCTURE_1e7z| PDB=1e7z | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e7z OCA], [http://www.ebi.ac.uk/pdbsum/1e7z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e7z RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE EMAP2/RNA BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX'''
'''CRYSTAL STRUCTURE OF THE EMAP2/RNA BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX'''
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[[Category: Pasqualato, S.]]
[[Category: Pasqualato, S.]]
[[Category: Renault, L.]]
[[Category: Renault, L.]]
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[[Category: ob-fold]]
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[[Category: Ob-fold]]
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[[Category: rna binding domain]]
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[[Category: Rna binding domain]]
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[[Category: trna synthetase complex]]
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[[Category: Trna synthetase complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:46:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:57:05 2008''
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Revision as of 11:46, 2 May 2008

Template:STRUCTURE 1e7z

CRYSTAL STRUCTURE OF THE EMAP2/RNA BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX


Overview

The EMAPII (endothelial monocyte-activating polypeptide II) domain is a tRNA-binding domain associated with several aminoacyl-tRNA synthetases, which becomes an independent domain with inflammatory cytokine activity upon apoptotic cleavage from the p43 component of the multisynthetase complex. It comprises a domain that is highly homologous to bacterial tRNA-binding proteins (Trbp), followed by an extra domain without homology to known proteins. Trbps, which may represent ancient tRNA chaperones, form dimers and bind one tRNA per dimer. In contrast, EMAPII domains are monomers. Here we report the crystal structure at 1.14 Angstroms of human EMAPII. The structure reveals that the Trbp-like domain, which forms an oligonucleotide-binding (OB) fold, is related by degenerate 2-fold symmetry to the extra-domain. The pseudo-axis coincides with the dyad axis of bacterial TtCsaA, a Trbp whose structure was solved recently. The interdomain interface in EMAPII mimics the intersubunit interface in TtCsaA, and may thus generate a novel OB-fold-based tRNA-binding site. The low sequence homology between the extra domain of EMAPII and either its own OB fold or that of Trbps suggests that dimer mimicry originated from convergent evolution rather than gene duplication.

About this Structure

1E7Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry., Renault L, Kerjan P, Pasqualato S, Menetrey J, Robinson JC, Kawaguchi S, Vassylyev DG, Yokoyama S, Mirande M, Cherfils J, EMBO J. 2001 Feb 1;20(3):570-8. PMID:11157763 Page seeded by OCA on Fri May 2 14:46:33 2008

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