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1mp9

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Revision as of 08:54, 21 April 2021

TBP from a mesothermophilic archaeon, Sulfolobus acidocaldarius

Structural highlights

1mp9 is a 2 chain structure with sequence from Atcc 33909. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TBP_SULAC] General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of TATA binding protein (TBP) from a mesothermophilic archaeon, Sulfolobus acidocaldarius, has been determined at a resolution of 2.0 A with an R factor of 20.9%. By comparing this structure with the structures of TBPs from a hyperthermophilic archaeon and mesophilic eukaryotes, as well as by comparing amino acid sequences of TBPs from archaea, covering a wide range of optimum growth temperatures, two significant determinants of the stability of TBP have been identified: increasing the interior hydrophobicity by interaction between three residues, Val, Leu, and Ile, with further differentiation of the surface, and increasing its hydrophilicity and raising the cost of unfolding. These findings suggest directions along which the stability of TBP can be engineered.

Origins of protein stability revealed by comparing crystal structures of TATA binding proteins.,Koike H, Kawashima-Ohya Y, Yamasaki T, Clowney L, Katsuya Y, Suzuki M Structure. 2004 Jan;12(1):157-68. PMID:14725775^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Koike H, Kawashima-Ohya Y, Yamasaki T, Clowney L, Katsuya Y, Suzuki M. Origins of protein stability revealed by comparing crystal structures of TATA binding proteins. Structure. 2004 Jan;12(1):157-68. PMID:14725775

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mp9"

@@ Line 3: / Line 3: @@
 <StructureSection load='1mp9' size='340' side='right'caption='[[1mp9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1mp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33909 Atcc 33909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MP9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1mp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33909 Atcc 33909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MP9 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mp9 OCA], [http://pdbe.org/1mp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mp9 RCSB], [http://www.ebi.ac.uk/pdbsum/1mp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mp9 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mp9 OCA], [https://pdbe.org/1mp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mp9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mp9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TBP_SULAC TBP_SULAC]] General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
+[[https://www.uniprot.org/uniprot/TBP_SULAC TBP_SULAC]] General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 29: @@
 ==See Also==
-*[[TATA-Binding Protein|TATA-Binding Protein]]
+*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
 == References ==
 <references/>

1mp9

From Proteopedia

Revision as of 08:54, 21 April 2021

TBP from a mesothermophilic archaeon, Sulfolobus acidocaldarius

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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