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1m2c
From Proteopedia
(Difference between revisions)
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<StructureSection load='1m2c' size='340' side='right'caption='[[1m2c]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''> | <StructureSection load='1m2c' size='340' side='right'caption='[[1m2c]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1m2c]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1m2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conma Conma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2C FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2c OCA], [https://pdbe.org/1m2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2c RCSB], [https://www.ebi.ac.uk/pdbsum/1m2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2c ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CA2_CONMA CA2_CONMA]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin blocks neuronal mammalian nAChRs (alpha-6 or -3/beta-2 or -3 > alpha-3/beta-2 > alpha-3/beta-4 = alpha-4/beta-2).<ref>PMID:11044728</ref> <ref>PMID:8631783</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 05:57, 28 April 2021
THREE-DIMENSIONAL STRUCTURE OF ALPHA-CONOTOXIN MII, NMR, 14 STRUCTURES
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Categories: Conma | Large Structures | Koerber, S C | Mcintosh, J M | Olivera, B M | Rivier, J E | Shon, K J | Cholinergic modulation | Dopamine release | Neuronal nicotinic acetylcholine receptor inhibitor | Neurotoxin | Presynaptic nicotinic acetylcholine receptor blocker | Subtype specific ligand
