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2fa4

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{{Seed}}
 
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[[Image:2fa4.png|left|200px]]
 
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==Crystal Structure of Oxidized Form from Saccharomyces cerevisiae==
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The line below this paragraph, containing "STRUCTURE_2fa4", creates the "Structure Box" on the page.
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<StructureSection load='2fa4' size='340' side='right'caption='[[2fa4]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fa4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FA4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ert|1ert]], [[1ep7|1ep7]]</div></td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fa4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fa4 OCA], [https://pdbe.org/2fa4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fa4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fa4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fa4 ProSAT]</span></td></tr>
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{{STRUCTURE_2fa4| PDB=2fa4 | SCENE= }}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/TRX2_YEAST TRX2_YEAST]] Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress.<ref>PMID:3060034</ref> <ref>PMID:9015301</ref> <ref>PMID:9657146</ref> <ref>PMID:10681558</ref> <ref>PMID:9988687</ref> <ref>PMID:11013218</ref> <ref>PMID:12437921</ref> <ref>PMID:12410842</ref> <ref>PMID:11169096</ref> <ref>PMID:12914955</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fa4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fa4 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Oxidized Form from Saccharomyces cerevisiae===
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==See Also==
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2FA4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FA4 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Atcc 18824]]
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<ref group="xtra">PMID:17044062</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Bao, R]]
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[[Category: Bao, R.]]
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[[Category: Chen, Y]]
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[[Category: Chen, Y.]]
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[[Category: Tang, Y J]]
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[[Category: Tang, Y J.]]
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[[Category: Zhou, C Z]]
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[[Category: Zhou, C Z.]]
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[[Category: Alpha/beta sandwich]]
[[Category: Alpha/beta sandwich]]
[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Electron transport]]
[[Category: Electron transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:50:10 2009''
 

Current revision

Crystal Structure of Oxidized Form from Saccharomyces cerevisiae

PDB ID 2fa4

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