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2ft2
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2ft2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ft2, resolution 1.700Å" /> '''Human Cathepsin S ...) |
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| - | [[Image:2ft2.gif|left|200px]]<br /> | ||
| - | <applet load="2ft2" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2ft2, resolution 1.700Å" /> | ||
| - | '''Human Cathepsin S with Inhibitor CRA-29728'''<br /> | ||
| - | == | + | ==Human Cathepsin S with Inhibitor CRA-29728== |
| - | + | <StructureSection load='2ft2' size='340' side='right'caption='[[2ft2]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2ft2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT2 FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C28:N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE'>C28</scene></td></tr> |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft2 OCA], [https://pdbe.org/2ft2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft2 ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [ | + | [[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft2_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ft2 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cathepsin S]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Somoza, J R]] | ||
| + | [[Category: Cysteine protease]] | ||
| + | [[Category: Proteinase]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Human Cathepsin S with Inhibitor CRA-29728
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