Enzyme-linked receptor
From Proteopedia
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==Activin receptor== | ==Activin receptor== | ||
*[[Activin receptor]] | *[[Activin receptor]] | ||
| - | + | 3D structure of the kinase domain of Activin receptor1 (Acvr1) complex with inhibitor shows <scene name='84/843934/Cv/3'>the inhibitor forming various interactions</scene> with the protein including a <scene name='84/843934/Cv/5'>hydrogen bonds to His residues</scene> and a <scene name='84/843934/Cv/6'>water bridged hydrogen bond to the catalytic lysine</scene><ref>PMID:25101911</ref>. Water molecule is shown as red sphere. | |
==Receptor-like serine/threonine protein kinase== | ==Receptor-like serine/threonine protein kinase== | ||
*[[Journal:Acta Cryst F:S2053230X20010122|Crystal structure of the extracellular domain of the receptor-like kinase TMK3 from ''Arabidopsis thaliana'']] | *[[Journal:Acta Cryst F:S2053230X20010122|Crystal structure of the extracellular domain of the receptor-like kinase TMK3 from ''Arabidopsis thaliana'']] | ||
Revision as of 11:10, 10 May 2021
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References and Notes
- ↑ Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15. doi: 10.1021/jm501177w. Epub 2014 Sep 4. PMID:25101911 doi:http://dx.doi.org/10.1021/jm501177w
