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2mr9
From Proteopedia
(Difference between revisions)
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==NMR structure of UBA domain of DNA-damage-inducible 1 protein (Ddi1)== | ==NMR structure of UBA domain of DNA-damage-inducible 1 protein (Ddi1)== | ||
| - | <StructureSection load='2mr9' size='340' side='right' caption='[[2mr9]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2mr9' size='340' side='right'caption='[[2mr9]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mr9]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2mr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MR9 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDI1, VSM1, YER143W ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDI1, VSM1, YER143W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mr9 OCA], [https://pdbe.org/2mr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mr9 RCSB], [https://www.ebi.ac.uk/pdbsum/2mr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mr9 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Baker's yeast]] | [[Category: Baker's yeast]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Fushman, D]] | [[Category: Fushman, D]] | ||
[[Category: Zhang, D]] | [[Category: Zhang, D]] | ||
Revision as of 15:19, 2 June 2021
NMR structure of UBA domain of DNA-damage-inducible 1 protein (Ddi1)
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