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2ny5
From Proteopedia
(Difference between revisions)
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==HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b== | ==HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b== | ||
| - | <StructureSection load='2ny5' size='340' side='right' caption='[[2ny5]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='2ny5' size='340' side='right'caption='[[2ny5]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ny5]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ny5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NY5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gc1|1gc1]], [[1rzj|1rzj]], [[1rzk|1rzk]], [[2nxy|2nxy]], [[2nxz|2nxz]], [[2ny0|2ny0]], [[2ny1|2ny1]], [[2ny2|2ny2]], [[2ny3|2ny3]], [[2ny4|2ny4]], [[2ny6|2ny6]], [[2ny7|2ny7]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gc1|1gc1]], [[1rzj|1rzj]], [[1rzk|1rzk]], [[2nxy|2nxy]], [[2nxz|2nxz]], [[2ny0|2ny0]], [[2ny1|2ny1]], [[2ny2|2ny2]], [[2ny3|2ny3]], [[2ny4|2ny4]], [[2ny6|2ny6]], [[2ny7|2ny7]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD4 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ny5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny5 OCA], [https://pdbe.org/2ny5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ny5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ny5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny5_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny5_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[CD4|CD4]] | + | *[[Antibody 3D structures|Antibody 3D structures]] |
| - | *[[3D structures of antibody|3D structures of antibody]] | + | *[[CD4 3D structures|CD4 3D structures]] |
| + | *[[Gp120 3D structures|Gp120 3D structures]] | ||
| + | *[[3D structures of human antibody|3D structures of human antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arthos, J]] | [[Category: Arthos, J]] | ||
[[Category: Burton, D R]] | [[Category: Burton, D R]] | ||
Revision as of 15:54, 8 June 2021
HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b
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Categories: Human | Large Structures | Arthos, J | Burton, D R | Dey, B | Dimitrov, D S | Hessell, A J | Kwong, P D | Nabel, G J | Ryk, D Van | Sodroski, J | Wyatt, R | Xiang, S H | Xu, L | Yang, X | Zhang, M Y | Zhou, T | Zwick, M B | Antibody | Cd4 | Gp120 | Hiv | Viral protein-immune system complex
