Cruzain
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1aim]], [[2aim]], [[1me3]], [[1me4]] – Cru catalytic domain + methylketone inhibitor | + | [[6n3s]] - Cru catalytic domain 123-337 - ''Trypanosoma cruzi'' <br /> |
| - | [[1f29]], [[1f2a]], [[1f2b]], [[1f2c]], [[1ewo]], [[3lxs]] - Cru catalytic domain + vinyl sulfone derived inhibitor<br /> | + | [[1aim]], [[2aim]], [[1me3]], [[1me4]], [[3iut]] – Cru catalytic domain + methylketone inhibitor<br /> |
| + | [[1f29]], [[1f2a]], [[1f2b]], [[1f2c]], [[1ewo]], [[2oz2]], [[3hd3]], [[3lxs]], [[6ux6]] - Cru catalytic domain + vinyl sulfone derived inhibitor<br /> | ||
[[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor<br /> | [[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor<br /> | ||
| + | [[1u9q]], [[3i06]], [[3kku]], [[4klb]], [[4pi3]], [[4qh6]], [[4w5b]], [[4w5c]], [[4xui]], [[6o2x]] - Cru catalytic domain + inhibitor<br /> | ||
[[1ewp]] - Cru catalytic domain + MOR-Leu-HPQ<br /> | [[1ewp]] - Cru catalytic domain + MOR-Leu-HPQ<br /> | ||
[[4w5b]], [[4xui]], [[4qh6]], [[4pi3]], [[4klb]], [[3kku]], [[3i06]], [[2oz2]], [[1u9q]] – TcPRO + inhibitor <br /> | [[4w5b]], [[4xui]], [[4qh6]], [[4pi3]], [[4klb]], [[3kku]], [[3i06]], [[2oz2]], [[1u9q]] – TcPRO + inhibitor <br /> | ||
Revision as of 08:01, 13 June 2021
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3D structures of cruzain
Updated on 13-June-2021
6n3s - Cru catalytic domain 123-337 - Trypanosoma cruzi
1aim, 2aim, 1me3, 1me4, 3iut – Cru catalytic domain + methylketone inhibitor
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 2oz2, 3hd3, 3lxs, 6ux6 - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1u9q, 3i06, 3kku, 4klb, 4pi3, 4qh6, 4w5b, 4w5c, 4xui, 6o2x - Cru catalytic domain + inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ
4w5b, 4xui, 4qh6, 4pi3, 4klb, 3kku, 3i06, 2oz2, 1u9q – TcPRO + inhibitor
4w5c, 3iut, 3hd3 – TcPRO (mutant) + inhibitor
References
- ↑ Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15;8(8):831-40. PMID:10997902
- ↑ Huang L, Brinen LS, Ellman JA. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain. Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703
