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CutA1

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{{STRUCTURE_1uku| PDB=1uku | SIZE=400| SCENE= |right|CAPTION=CutA1 complex with copper, [[1uku]] }}
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<StructureSection load='1uku' size='350' side='right' caption='CutA1 complex with copper (PDB entry [[1uku]])' scene='50/508403/Cv/1'>
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'''CutA1''' is involved in copper tolerance in E. coli. In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane. The thermostability of CutA1 from Pyrococcus horikoshii is extremely high. For more details see [[Divalent cation tolerant protein CUTA from Homo sapiens O60888]].
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'''CutA1''' or '''periplasmic divalent cation tolerance protein''' is involved in copper tolerance in ''E. coli''. In mammals it is implicated in the anchoring of acetylcholinesterase in the neural cell membrane. The thermostability of CutA1 from ''Pyrococcus horikoshii'' is extremely high.<ref>PMID:14706845</ref> See [[Divalent cation tolerant protein CUTA from Homo sapiens O60888]].
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==3D structures of CutA1==
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== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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The <scene name='50/508403/Cv/2'>copper ion is bound to Asp and Lys residues</scene>.
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[[1kr4]], [[1o5j]], [[1vhf]] – TmCutA – ''Thermotoga maritima''<br />
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==3D structures of CutA1==
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[[1nza]], [[1v6h]] – CutA – ''Thermus thermophilus''<br />
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[[CutA1 3D structures]]
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[[1p1l]] – CutA – ''Archaeoglobus fulgidus''<br />
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[[1naq]] – EcCutA – ''Escherichia coli''<br />
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[[3aa8]], [[3aa9]], [[3ah6]] - EcCutA (mutant)<br />
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[[1osc]] – CutA – rat<br />
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[[1xk8]] – CutA – human<br />
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[[2zom]] - CutA - rice<br />
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[[1j2v]] – PhCutA – ''Pyrococcus horikoshii''<br />
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[[3gsd]] - CutA – ''Yersinia pestis''<br />
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[[3opk]] - CutA – ''Salmonella enterica''<br />
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[[2e66]] - PhCutA (mutant)<br />
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[[3ahp]] – CutA – ''Shewanella''<br />
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[[4iyq]] – CutA – ''Ehrlichia chaffeensis''<br />
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[[4e98]] – CutA – ''Cryptosporidium parvum''<br />
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===CutA1 binary complex===
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[[1uku]], [[1v99]] – PhCutA + Cu<br />
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</StructureSection>
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[[1v9b]] - PhCutA + Co<br />
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[[1umj]] - PhCutA + guanidine
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

CutA1 complex with copper (PDB entry 1uku)

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References

  1. ↑ Tanaka Y, Tsumoto K, Nakanishi T, Yasutake Y, Sakai N, Yao M, Tanaka I, Kumagai I. Structural implications for heavy metal-induced reversible assembly and aggregation of a protein: the case of Pyrococcus horikoshii CutA. FEBS Lett. 2004 Jan 2;556(1-3):167-74. PMID:14706845

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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