Cytidine monophosphate kinase

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(New page: <StructureSection load='2cmk' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CDP (PDB entry 2cmk)' scene=''> '''Cytidine monopho...)
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<StructureSection load='' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry [[1kdo]])' scene='57/573961/Cv/1'>
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<StructureSection load='2cmk' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CDP (PDB entry [[2cmk]])' scene=''>
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'''Cytidine monophosphate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP.
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'''Cytidine monophosphate kinase''' or '''cytidylate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. <ref>PMID:9862805</ref>
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== Relevance ==
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CMK from bacterial pathogens is a target for new antibiotics development.
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== Structural highlights ==
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<scene name='57/573961/Cv/4'>CMK active site</scene> is highly sugar-specific.<ref>PMID:11827479</ref> Water molecules are shown as red spheres.
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</StructureSection>
==3D structures of cytidine monophosphate kinase==
==3D structures of cytidine monophosphate kinase==
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[[1cke]] – EcCMK – ''Escherichia coli''<br />
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(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}})
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[[2fem]] – EcCMK (mutant)<br />
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[[1q3t]] – CMK – ''Streptococcus pneumoniae''<br />
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[3r8c]] – MaCMK – ''Mycobacterium abscessus''<br />
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[[3r20]] – CMK – ''Mycobacterium smegmatis''<br />
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*CMK
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[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br />
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[[3w90]] – TtCMK – ''Thermus thermophilus''<br />
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**[[1tev]] – CMK – human<br />
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**[[1cke]] – EcCMK – ''Escherichia coli''<br />
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**[[2fem]] – EcCMK (mutant)<br />
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**[[1q3t]] – CMK – ''Streptococcus pneumoniae''<br />
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**[[3r8c]] – MaCMK – ''Mycobacterium abscessus''<br />
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**[[3r20]] – CMK – ''Mycobacterium smegmatis''<br />
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**[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br />
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**[[3w90]] – TtCMK – ''Thermus thermophilus''<br />
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===CMK complex with liga
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*CMK complex with ligand
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[[2cmk]] – EcCMK + CDP<br />
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**[[2cmk]] – EcCMK + CDP<br />
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[[3akd]] – TtCMK + CDP <br />
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**[[3akd]] – TtCMK + CDP <br />
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[[3ake]], [[3w8n]] – TtCMK + CMP<br />
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**[[7ckj]], [[3w8n]] – TtCMK + CMP<br />
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[[4die]] – MaCMK + CMP<br />
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**[[4die]] – MaCMK + CMP<br />
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[[1kdo]] – EcCMK + CMP<br />
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**[[1kdo]] – EcCMK + CMP<br />
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[[1kdp]] – EcCMK + dCMP<br />
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**[[1kdp]] – EcCMK + dCMP<br />
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[[2feo]] – EcCMK (mutant) + dCMP<br />
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**[[2feo]] – EcCMK (mutant) + dCMP<br />
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[[1kdr]] – EcCMK + ara-CMP<br />
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**[[1kdr]] – EcCMK + ara-CMP<br />
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[[1kdt]] – EcCMK + ddCMP<br />
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**[[1kdt]] – EcCMK + ddCMP<br />
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[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br />
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**[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br />
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[[3akc]] – TtCMK + CDP + ADP <br />
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**[[7ckj]] – TtCMK + CMP <br />
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**[[3akc]] – TtCMK + CDP + ADP <br />
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**[[7l4a]] – CMK + CDP – ''Encephalitozoon cuniculi''<br />
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}}
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== References ==
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<references/>
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[[Category: Topic Page]]

Current revision

Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry 1kdo)

Drag the structure with the mouse to rotate

3D structures of cytidine monophosphate kinase

(Updated on 16-June-2021)

References

  1. ↑ Briozzo P, Golinelli-Pimpaneau B, Gilles AM, Gaucher JF, Burlacu-Miron S, Sakamoto H, Janin J, Barzu O. Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity. Structure. 1998 Dec 15;6(12):1517-27. PMID:9862805
  2. ↑ Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Barzu O, Gilles AM. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme. J Mol Biol. 2002 Feb 1;315(5):1099-110. PMID:11827479 doi:10.1006/jmbi.2001.5286

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