Cytidine monophosphate kinase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry [[1kdo]])' scene='57/573961/Cv/1'> |
| - | '''Cytidine monophosphate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. <ref>PMID:9862805</ref> | + | '''Cytidine monophosphate kinase''' or '''cytidylate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. <ref>PMID:9862805</ref> |
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='57/573961/Cv/ | + | <scene name='57/573961/Cv/4'>CMK active site</scene> is highly sugar-specific.<ref>PMID:11827479</ref> Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
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*CMK | *CMK | ||
| + | **[[1tev]] – CMK – human<br /> | ||
**[[1cke]] – EcCMK – ''Escherichia coli''<br /> | **[[1cke]] – EcCMK – ''Escherichia coli''<br /> | ||
**[[2fem]] – EcCMK (mutant)<br /> | **[[2fem]] – EcCMK (mutant)<br /> | ||
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**[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br /> | **[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br /> | ||
**[[3w90]] – TtCMK – ''Thermus thermophilus''<br /> | **[[3w90]] – TtCMK – ''Thermus thermophilus''<br /> | ||
| - | **[[1tev]] – CMK – human<br /> | ||
*CMK complex with ligand | *CMK complex with ligand | ||
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**[[2cmk]] – EcCMK + CDP<br /> | **[[2cmk]] – EcCMK + CDP<br /> | ||
**[[3akd]] – TtCMK + CDP <br /> | **[[3akd]] – TtCMK + CDP <br /> | ||
| - | **[[ | + | **[[7ckj]], [[3w8n]] – TtCMK + CMP<br /> |
**[[4die]] – MaCMK + CMP<br /> | **[[4die]] – MaCMK + CMP<br /> | ||
**[[1kdo]] – EcCMK + CMP<br /> | **[[1kdo]] – EcCMK + CMP<br /> | ||
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**[[1kdt]] – EcCMK + ddCMP<br /> | **[[1kdt]] – EcCMK + ddCMP<br /> | ||
**[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br /> | **[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br /> | ||
| + | **[[7ckj]] – TtCMK + CMP <br /> | ||
**[[3akc]] – TtCMK + CDP + ADP <br /> | **[[3akc]] – TtCMK + CDP + ADP <br /> | ||
| + | **[[7l4a]] – CMK + CDP – ''Encephalitozoon cuniculi''<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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3D structures of cytidine monophosphate kinase
(Updated on 16-June-2021)
References
- ↑ Briozzo P, Golinelli-Pimpaneau B, Gilles AM, Gaucher JF, Burlacu-Miron S, Sakamoto H, Janin J, Barzu O. Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity. Structure. 1998 Dec 15;6(12):1517-27. PMID:9862805
- ↑ Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Barzu O, Gilles AM. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme. J Mol Biol. 2002 Feb 1;315(5):1099-110. PMID:11827479 doi:10.1006/jmbi.2001.5286
