Deaminase

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Structure of yeast cytosine deaminase complex with pyrimidine-based inhibitor, acetate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 1p6o)

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References

↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
↑ Feng M, Harijan RK, Harris LD, Tyler PC, Frohlich RFG, Brown M, Schramm VL. Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori. Biochemistry. 2021 Jun 22;60(24):1933-1946. doi: 10.1021/acs.biochem.1c00215., Epub 2021 Jun 2. PMID:34077175 doi:http://dx.doi.org/10.1021/acs.biochem.1c00215
↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
↑ Ireton GC, Black ME, Stoddard BL. The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003 Aug;11(8):961-72. PMID:12906827

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Deaminase"

Category: Topic Page

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 * '''L-serine deaminase''' (LSD) converts L-serine to pyruvate.<br />
 * '''D-serine deaminase''' (DSD) converts D-serine to pyruvate.<br />
+* '''Aminofutalosine deaminase''' deaminates aminofutalosine which is an intermediate in the menaquinone biosynthesis in ''Helicobacter pylori'' <ref>PMID:34077175</ref>. <br />
 == Relevance ==
@@ Line 35: / Line 36: @@
 </StructureSection>
-== 3D Structures of deaminase ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Cytidine deaminase
-**[[1r5t]] – yCDA - yeast <BR />
-**[[2a8n]] – AtCDA – ''Agrobacterium tumefaciens'' <BR />
-**[[2g84]] – NeCDA – ''Nitrosomonas europaea'' <BR />
-**[[2d30]] – CDA – ''Bacillus anthracis'' <BR />
-**[[3dmo]] – CDA – ''Burkholderia pseudomallei''   <BR />
-**[[3ijf]] – MtCDA – ''Mycobacterium tuberculosis'' <BR />
-**[[4wif]], [[4wig]] – MtCDA (mutant)   <BR />
-**[[3mpz]] – CDA – ''Mycobacterium smegmatis'' <BR />
-**[[3r2n]] – CDA – ''Mycobacterium leprae'' <BR />
-**[[4f3w]] – CDA – ''Mycobacterium marinum'' <BR />
-*''Cytidine deaminase complex with nucleoside''
-**[[1ctt]] – EcCDA + dihydro-pyrimidinone – ''Escherichia coli''  <BR />
-**[[1ctu]] – EcCDA + hydroxyl-dihydro-zebularine   <BR />
-**[[1af2]] – EcCDA + uridine   <BR />
-**[[1aln]] – EcCDA + deazacytidine   <BR />
-**[[1jtk]] – BsCDA + tetrahydrodeoxyuridine  - ''Bacillus subtilis'' <BR />
-**[[1uwz]], [[1ux0]], [[1ux1]] – BsCDA (mutant) + tetrahydrodeoxyuridine   <BR />
-**[[1mq0]] – hCDA + β-ribofuranosyl diazepinone - human <BR />
-**[[1zab]] – mCDA + deazauridine - mouse  <BR />
-**[[2fr5]] – mCDA + tetrahydrouridine  <BR />
-**[[2fr6]] – mCDA + cytidine + uridine  <BR />
-**[[4eg2]] – CDA + uridine - ''Vibrio cholerae'' <BR />
-*Cytosine deaminase
-**[[1k6w]] – EcCDDA  <BR />
-**[[1r9x]], [[1r9y]], [[1r9z]], [[1ra0]], [[1ra5]], [[3g77]]  – EcCDDA  (mutant)<BR />
-**[[1rb7]], [[1uaq]] – yCDDA  <BR />
-**[[1ysb]], [[1ysd]]  – yCDDA  (mutant)<BR />
-*''Cytosine deaminase complex''
-**[[3r0d]] – EcCDDA + Zn <BR />
-**[[3rn6]] – EcCDDA + Zn + iso-guanine<BR />
-**[[1k70]] – EcCDDA  + pyrimidine derivative<BR />
-**[[1rak]] – EcCDDA  (mutant) + pyrimidine derivative<BR />
-**[[3o7u]] – EcCDDA + Zn + phosphono-cytosine<BR />
-**[[1ox7]] – yCDDA + Zn <BR />
-**[[1p6o]] – yCDDA  + pyrimidine derivative<BR />
-**[[2o3k]] – yCDDA  (mutant) + pyrimidine derivative<BR />
-**[[4r7w]], [[4r85]], [[4r88]] – KpCDDA  + cytosine derivative – ''Klebsiella pneumoniae''<BR />
-* Deoxycytidylate deaminase
-**[[2hvv]], [[2hvw]] – SmDCMP  - ''Streptococcus mutans'' <BR />
-**[[1vq2]] – DCMP  - Enterobacteria phage T4 <BR />
-**[[4p9c]] – CyDCMP + deoxyCMP - Cyanophage S-TIM5 <BR />
-**[[4p9d]] – CyDCMP + TMP <BR />
-**[[4p9e]] – CyDCMP  <BR />
-**[[2w4l]] – hDCMP<BR />
-**[[5jfy]] – DCMP - cabbage<BR />
-*Guanine deaminase
-**[[1tiy]], [[1wkq]] – BsGDA  <BR />
-**[[3e0l]] – hGDA<br />
-*''Guanine deaminase complex with nucleoside''
-**[[2i9u]] – GDA + guanine – ''Clostridium acetobutylicum'' <BR />
-**[[2ood]] – GDA + guanine – ''Bradrhizobium japonicum'' <BR />
-**[[4lc5]], [[4lcn]], [[4hrq]] – NeGDA + guanine  derivative<BR />
-**[[4hrw]] – NeGDA (mutant) + guanine  derivative<BR />
-**[[4lco]] – NeGDA + ameline<BR />
-**[[4lcp]] – NeGDA + diaminopurine<BR />
-**[[4ld2]] – NeGDA + cytidine<BR />
-**[[4ld4]] – NeGDA + cytosine<BR />
-**[[2uz9]] – hGDA + xanthine   <BR />
-**[[4aql]] – hGDA + valacyclovir  <BR />
-*Adenine deaminase
-**[[2ics]] – ADA  - ''Enterococcus faecalis''<BR />
-**[[3nqb]], [[3t81]], [[3t8l]] – AtADA  <BR />
-*Adenosine deaminase See [[Adenosine deaminase]]
-*Glucosamine 6-phosphate deaminase
-**[[1dea]], [[1cd5]], [[1fs6]], [[1fsf]] – EcGPD  <BR />
-**[[1jt9]] – EcGPD  (mutant) <BR />
-**[[2ri0]] – SmGPD – ''Streptococcus mutans'' <BR />
-**[[6nbg]] – KpGPD  <BR />
-**[[3hn6]] – GPD – ''Borrelia burgdorferi''<br />
-**[[1j5x]] – GPD – ''Thermotoga maritima''<br />
-**[[2bkv]] – BsGPD <br />
-**[[2bkx]] – BsGPD  + fructose 6-phosphate<BR />
-**[[4r7t]] – VcGPD <br />
-**[[5hj5]] – VcGPD  + fructose 6-phosphate + glucose-6-phosphate<BR />
-**[[1hor]] – EcGPD  + deoxy-amino glucitol-phosphate<BR />
-**[[1hot]], [[1frz]], [[1fs5]], [[2wu1]] – EcGPD  + N-acetyl-glucosamine-6-phosphate<BR />
-**[[1fqo]] – EcGPD  + fructose 6-phosphate<BR />
-**[[2ri1]] – SmGPD  + glucosamine-6-phosphate<BR />
-*1-aminocyclopropane-1-carboxylate (ACC) deaminase
-**[[1f2d]] – WsACCD + PLP – ''Williopsis saturnus''<BR />
-**[[1j0c]] – WsACCD (mutant) + PLP <BR />
-**[[1j0d]] – WsACCD (mutant) + inhibitor<BR />
-**[[1j0e]] – WsACCD (mutant) + PLP + ACC<BR />
-**[[1j0a]] – PhACCD + PLP + 2-propanol – ''Pyrococcus horikoshii''<BR />
-**[[1j0b]] – PhACCD + inhibitor<BR />
-**[[1tyz]] – PsACCD + PLP - ''Pseudomonas''<BR />
-**[[1rqx]] – PsACCD + PLP + inhibitor <BR />
-**[[1tz2]] – PsACCD + PLP + ACC<BR />
-**[[1tzj]] – PsACCD + PLP + vinylglycine<BR />
-**[[1tzk]] – PsACCD + PLP + α-ketobutyrate<BR />
-**[[1tzm]] – PsACCD + PLP + chloroalanine<BR />
-*dCTP deaminase
-**[[2qlp]] – MtCTPD  <BR />
-**[[3km3]] – CTPD – ''Anaplasma phagocytophilum''<br />
-**[[4dhk]] – CTPD  - ''Burkholderia thailandensis''<BR />
-*''dCTP deaminase complex''
-**[[1xs1]] – EcCTPD  + dUTP<BR />
-**[[1xs4]] – EcCTPD  (mutant) + dCTP<BR />
-**[[2j4h]] – EcCTPD  (mutant) + dCDP<BR />
-**[[1xs6]], [[2v9x]] – EcCTPD  (mutant) + dUTP<BR />
-**[[2j4q]] – EcCTPD  (mutant) + dTTP + dTDP<BR />
-**[[2qxx]] – MtCTPD  + dTTP<BR />
-*dCTP deaminase-dUTPase
-**[[2hxb]], [[1ogh]], [[1pkh]], [[3gf0]] – MjDCD-DUT – ''Methanocaldococcus jannaschii'' <BR />
-**[[1pkj]] – MjDCD-DUT + dUTP<BR />
-**[[2hxd]] – MjDCD-DUT (mutant) + dUTP derivative<BR />
-**[[1pkk]] – MjDCD-DUT + dCTP<BR />
-**[[4xjc]] – DCD-DUT + TTP – ''Bacillus halodurans''<BR />
-**[[4a6a]] – MtDCD-DUT (mutant) + TTP <BR />
-*Porphobilinogen deaminase See [[Porphobilinogen Deaminase]]
-*Blasticidin-S deaminase
-**[[1wn5]], [[2z3g]] – AtBSD – ''Aspergillus terreus'' <BR />
-**[[2z3j]] – AtBSD (mutant) <BR />
-**[[3oj6]] – BSD – Coccidioides immitis <BR />
-**[[1wn6]] – AtBSD + blasticidin-S intermediate<BR />
-**[[2z3h]] – AtBSD + deaminohydroxy blasticidin-S <BR />
-**[[2z3i]] – AtBSD (mutant) + blasticidin-S <BR />
-*Threonine deaminase
-**[[1tdj]] – EcTHD + PLP <BR />
-**[[2gn0]], [[2gn1]] – StTHD + PLP derivative – ''Salmonella typhimurium''<BR />
-**[[2gn2]] – StTHD + PLP derivative + CMP<BR />
-**[[3iau]] – THD + PLP derivative – tomato<BR />
-**[[1ve5]] – THD + PLP – ''Thermus thermophilus''<BR />
-*L-serine deaminase
-**[[1pwe]] – rLSD - rat <BR />
-**[[1p5j]], [[2rkb]] – hLSD (mutant) + PLP <BR />
-**[[1pwh]] – rLSD + PLP derivative <BR />
-*D-serine deaminase
-**[[3r0x]], [[3r0z]] – DSD – ''Salmonella enterica''<BR />
-**[[3ss7]], [[3ss9]] – EcDSD + PLP <BR />
-**[[3gwq]] – DSD  - ''Burkholderia xenovorans''<BR />
-*L-amino acid deaminase
-**[[5fjm]] – PmLSD – ''Proteus myxofaciens'' <BR />
-**[[5fjn]] – PmLSD + anthranilate  <BR />
-**[[5i39]], [[5hxw]] – LSD + FAD – ''Proteus vulgaris'' <BR />
-*2-aminomuconate deaminase
-**[[6izh]] – PsAMD –  <BR />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

Deaminase

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