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2q05

From Proteopedia

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[[Image:2q05.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR==
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|PDB= 2q05 |SIZE=350|CAPTION= <scene name='initialview01'>2q05</scene>, resolution 2.57&Aring;
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<StructureSection load='2q05' size='340' side='right'caption='[[2q05]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2q05]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccw Vaccw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q05 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|GENE= H1L, VACWR099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 Vaccinia virus WR])
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H1L, VACWR099 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 VACCW])</td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q05 OCA], [https://pdbe.org/2q05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q05 RCSB], [https://www.ebi.ac.uk/pdbsum/2q05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q05 ProSAT], [https://www.topsan.org/Proteins/MCSG/2q05 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/2q05_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q05 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR'''
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==See Also==
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*[[MAP kinase phosphatase|MAP kinase phosphatase]]
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== References ==
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==About this Structure==
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<references/>
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2Q05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_wr Vaccinia virus wr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q05 OCA].
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Vaccinia virus wr]]
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[[Category: Large Structures]]
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[[Category: Edwards, A.]]
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[[Category: Vaccw]]
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[[Category: Joachimiak, A.]]
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[[Category: Edwards, A]]
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[[Category: Kagan, O.]]
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[[Category: Joachimiak, A]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Kagan, O]]
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[[Category: Osipiuk, J.]]
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[[Category: Structural genomic]]
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[[Category: Savchenko, A.]]
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[[Category: Osipiuk, J]]
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[[Category: Skarina, T.]]
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[[Category: Savchenko, A]]
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[[Category: apc7320]]
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[[Category: Skarina, T]]
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[[Category: mcsg]]
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[[Category: Apc7320]]
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[[Category: midwest center for structural genomic]]
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[[Category: Hydrolase]]
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[[Category: phosphatase]]
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[[Category: Mcsg]]
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[[Category: protein structure initiative]]
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[[Category: Phosphatase]]
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[[Category: psi-2]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: structural genomic]]
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[[Category: Vaccinia virus]]
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[[Category: vaccinia virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:20:06 2008''
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Current revision

Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR

PDB ID 2q05

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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