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2q05

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==Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR==
==Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR==
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<StructureSection load='2q05' size='340' side='right' caption='[[2q05]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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<StructureSection load='2q05' size='340' side='right'caption='[[2q05]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2q05]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccw Vaccw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q05 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2q05]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccw Vaccw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q05 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H1L, VACWR099 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 VACCW])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H1L, VACWR099 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 VACCW])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q05 OCA], [http://pdbe.org/2q05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2q05 RCSB], [http://www.ebi.ac.uk/pdbsum/2q05 PDBsum], [http://www.topsan.org/Proteins/MCSG/2q05 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q05 OCA], [https://pdbe.org/2q05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q05 RCSB], [https://www.ebi.ac.uk/pdbsum/2q05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q05 ProSAT], [https://www.topsan.org/Proteins/MCSG/2q05 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref>
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[[https://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/2q05_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/2q05_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q05 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Vaccw]]
[[Category: Vaccw]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]

Current revision

Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR

PDB ID 2q05

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