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2q1m

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{{Seed}}
 
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[[Image:2q1m.png|left|200px]]
 
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<!--
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==Crystal Structure of human GITRL==
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The line below this paragraph, containing "STRUCTURE_2q1m", creates the "Structure Box" on the page.
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<StructureSection load='2q1m' size='340' side='right'caption='[[2q1m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q1M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF18, AITRL, GITRL, TL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q1m OCA], [https://pdbe.org/2q1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q1m RCSB], [https://www.ebi.ac.uk/pdbsum/2q1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q1m ProSAT]</span></td></tr>
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{{STRUCTURE_2q1m| PDB=2q1m | SCENE= }}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/TNF18_HUMAN TNF18_HUMAN]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:17449724</ref> <ref>PMID:18040044</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/2q1m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q1m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glucocorticoid-induced TNF receptor ligand (GITRL), a recently identified member of the TNF family, binds to its receptor GITR on both effector and regulatory T cells and generates positive costimulatory signals implicated in a wide range of T cell functions. Structural analysis reveals that the human GITRL (hGITRL) ectodomain self-assembles into an atypical expanded homotrimer with sparse monomer-monomer interfaces. Consistent with the small intersubunit interfaces, hGITRL exhibits a relatively weak tendency to trimerize in solution and displays a monomer-trimer equilibrium not reported for other TNF family members. This unique assembly behavior has direct implications for hGITRL-GITR signaling, because enforced trimerization of soluble hGITRL ectodomain results in an approximately 100-fold increase in its receptor binding affinity and also in enhanced costimulatory activity. The apparent reduction in affinity that is the consequence of this dynamic equilibrium may represent a mechanism to realize the biologically optimal level of signaling through the hGITRL-GITR pathway, as opposed to the maximal achievable level.
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===Crystal Structure of human GITRL===
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Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.,Chattopadhyay K, Ramagopal UA, Mukhopadhaya A, Malashkevich VN, Dilorenzo TP, Brenowitz M, Nathenson SG, Almo SC Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19452-7. Epub 2007 Nov 26. PMID:18040044<ref>PMID:18040044</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2q1m" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18040044}}, adds the Publication Abstract to the page
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*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18040044 is the PubMed ID number.
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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-->
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== References ==
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{{ABSTRACT_PUBMED_18040044}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2Q1M is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1M OCA].
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[[Category: Human]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Almo, S C]]
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<ref group="xtra">PMID:18040044</ref><references group="xtra"/>
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[[Category: Chattopadhyay, K]]
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[[Category: Homo sapiens]]
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[[Category: Nathenson, S G]]
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[[Category: Almo, S C.]]
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[[Category: Ramagopal, U A]]
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[[Category: Chattopadhyay, K.]]
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[[Category: Nathenson, S G.]]
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[[Category: Ramagopal, U A.]]
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[[Category: Gitrl]]
[[Category: Gitrl]]
[[Category: Glucocorticoid-induced tnf receptor ligand]]
[[Category: Glucocorticoid-induced tnf receptor ligand]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:46:18 2009''
 

Current revision

Crystal Structure of human GITRL

PDB ID 2q1m

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