This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2q2f
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2q2f" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q2f, resolution 1.50Å" /> '''Structure of the hu...) |
|||
| (13 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2q2f.gif|left|200px]]<br /> | ||
| - | <applet load="2q2f" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2q2f, resolution 1.50Å" /> | ||
| - | '''Structure of the human Selenoprotein S (VCP-interacting membrane protein)'''<br /> | ||
| - | == | + | ==Structure of the human Selenoprotein S (VCP-interacting membrane protein)== |
| - | + | <StructureSection load='2q2f' size='340' side='right'caption='[[2q2f]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2q2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q2F FirstGlance]. <br> |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SELS, VIMP, AD-015, SBBI8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[Category: Arrowsmith, C | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q2f OCA], [https://pdbe.org/2q2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q2f RCSB], [https://www.ebi.ac.uk/pdbsum/2q2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q2f ProSAT]</span></td></tr> |
| - | [[Category: Bochkarev, A | + | </table> |
| - | [[Category: Butler-Cole, C | + | == Function == |
| - | [[Category: Dhe-Paganon, S | + | [[https://www.uniprot.org/uniprot/SELS_HUMAN SELS_HUMAN]] Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.<ref>PMID:15215856</ref> |
| - | [[Category: Edwards, A | + | == Evolutionary Conservation == |
| - | [[Category: Paramanathan, R | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: Sundstrom, M | + | <jmolCheckbox> |
| - | [[Category: Walker, J | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q2/2q2f_consurf.spt"</scriptWhenChecked> |
| - | [[Category: Weigelt, J | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q2f ConSurf]. | |
| - | [[Category: | + | <div style="clear:both"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Arrowsmith, C H]] | |
| - | + | [[Category: Bochkarev, A]] | |
| - | + | [[Category: Butler-Cole, C]] | |
| + | [[Category: Dhe-Paganon, S]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Paramanathan, R]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Sundstrom, M]] | ||
| + | [[Category: Walker, J R]] | ||
| + | [[Category: Weigelt, J]] | ||
| + | [[Category: Anti-parallel coiled-coil]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Selenium]] | ||
| + | [[Category: Selenocysteine]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transmembrane]] | ||
Current revision
Structure of the human Selenoprotein S (VCP-interacting membrane protein)
| |||||||||||
Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Butler-Cole, C | Dhe-Paganon, S | Edwards, A M | Paramanathan, R | Structural genomic | Sundstrom, M | Walker, J R | Weigelt, J | Anti-parallel coiled-coil | Endoplasmic reticulum | Membrane | Membrane protein | Selenium | Selenocysteine | Sgc | Transmembrane
