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2q2f

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{{Seed}}
 
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[[Image:2q2f.png|left|200px]]
 
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==Structure of the human Selenoprotein S (VCP-interacting membrane protein)==
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The line below this paragraph, containing "STRUCTURE_2q2f", creates the "Structure Box" on the page.
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<StructureSection load='2q2f' size='340' side='right'caption='[[2q2f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q2F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2q2f| PDB=2q2f | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SELS, VIMP, AD-015, SBBI8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q2f OCA], [https://pdbe.org/2q2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q2f RCSB], [https://www.ebi.ac.uk/pdbsum/2q2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q2f ProSAT]</span></td></tr>
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===Structure of the human Selenoprotein S (VCP-interacting membrane protein)===
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SELS_HUMAN SELS_HUMAN]] Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.<ref>PMID:15215856</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2Q2F is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q2F OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
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Check<jmol>
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[[Category: Arrowsmith, C H.]]
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<jmolCheckbox>
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[[Category: Bochkarev, A.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q2/2q2f_consurf.spt"</scriptWhenChecked>
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[[Category: Butler-Cole, C.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Dhe-Paganon, S.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Edwards, A M.]]
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</jmolCheckbox>
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[[Category: Paramanathan, R.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q2f ConSurf].
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[[Category: SGC, Structural Genomics Consortium.]]
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<div style="clear:both"></div>
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[[Category: Sundstrom, M.]]
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== References ==
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[[Category: Walker, J R.]]
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<references/>
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[[Category: Weigelt, J.]]
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bochkarev, A]]
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[[Category: Butler-Cole, C]]
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[[Category: Dhe-Paganon, S]]
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[[Category: Edwards, A M]]
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[[Category: Paramanathan, R]]
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[[Category: Structural genomic]]
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[[Category: Sundstrom, M]]
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[[Category: Walker, J R]]
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[[Category: Weigelt, J]]
[[Category: Anti-parallel coiled-coil]]
[[Category: Anti-parallel coiled-coil]]
[[Category: Endoplasmic reticulum]]
[[Category: Endoplasmic reticulum]]
[[Category: Membrane]]
[[Category: Membrane]]
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[[Category: Membrane protein]]
[[Category: Selenium]]
[[Category: Selenium]]
[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:39:25 2009''
 

Current revision

Structure of the human Selenoprotein S (VCP-interacting membrane protein)

PDB ID 2q2f

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