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2q3f
From Proteopedia
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==X-ray crystal structure of putative human Ras-related GTP binding D in complex with GMPPNP== | ==X-ray crystal structure of putative human Ras-related GTP binding D in complex with GMPPNP== | ||
| - | <StructureSection load='2q3f' size='340' side='right' caption='[[2q3f]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='2q3f' size='340' side='right'caption='[[2q3f]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2q3f]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2q3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3F FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAGD ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAGD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3f OCA], [https://pdbe.org/2q3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3f RCSB], [https://www.ebi.ac.uk/pdbsum/2q3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3f ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/RRAGD_HUMAN RRAGD_HUMAN]] Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.<ref>PMID:20381137</ref> <ref>PMID:11073942</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3f_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3f_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3f ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Large Structures]] |
| - | [[Category: Bochkarev, A | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Edwards, A M | + | [[Category: Bochkarev, A]] |
| - | [[Category: Keefe, L J | + | [[Category: Edwards, A M]] |
| - | [[Category: Landry, R | + | [[Category: Keefe, L J]] |
| - | [[Category: Mulichak, A M | + | [[Category: Landry, R]] |
| - | [[Category: Nedyalkova, L | + | [[Category: Mulichak, A M]] |
| - | [[Category: Park, H | + | [[Category: Nedyalkova, L]] |
| - | [[Category: Rabeh, W M | + | [[Category: Park, H]] |
| - | [[Category: | + | [[Category: Rabeh, W M]] |
| - | [[Category: Sundstrom, M | + | [[Category: Structural genomic]] |
| - | [[Category: Tempel, W | + | [[Category: Sundstrom, M]] |
| - | [[Category: Weigelt, J | + | [[Category: Tempel, W]] |
| + | [[Category: Weigelt, J]] | ||
[[Category: Gtp-binding]] | [[Category: Gtp-binding]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Rragd]] | [[Category: Rragd]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Current revision
X-ray crystal structure of putative human Ras-related GTP binding D in complex with GMPPNP
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Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Edwards, A M | Keefe, L J | Landry, R | Mulichak, A M | Nedyalkova, L | Park, H | Rabeh, W M | Structural genomic | Sundstrom, M | Tempel, W | Weigelt, J | Gtp-binding | Protein binding | Rragd | Sgc
