This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2q3f
From Proteopedia
(Difference between revisions)
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2q3f.gif|left|200px]] | ||
| - | + | ==X-ray crystal structure of putative human Ras-related GTP binding D in complex with GMPPNP== | |
| - | + | <StructureSection load='2q3f' size='340' side='right'caption='[[2q3f]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | | | + | <table><tr><td colspan='2'>[[2q3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3F FirstGlance]. <br> |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | | | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAGD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3f OCA], [https://pdbe.org/2q3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3f RCSB], [https://www.ebi.ac.uk/pdbsum/2q3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3f ProSAT]</span></td></tr> | |
| - | ''' | + | </table> |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/RRAGD_HUMAN RRAGD_HUMAN]] Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.<ref>PMID:20381137</ref> <ref>PMID:11073942</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | [[Category: Arrowsmith, C H | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3f_consurf.spt"</scriptWhenChecked> |
| - | [[Category: Bochkarev, A | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: Edwards, A M | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: Keefe, L J | + | </jmolCheckbox> |
| - | [[Category: Landry, R | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3f ConSurf]. |
| - | [[Category: Mulichak, A M | + | <div style="clear:both"></div> |
| - | [[Category: Nedyalkova, L | + | == References == |
| - | [[Category: Park, H | + | <references/> |
| - | [[Category: Rabeh, W M | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Sundstrom, M | + | [[Category: Human]] |
| - | [[Category: Tempel, W | + | [[Category: Large Structures]] |
| - | [[Category: Weigelt, J | + | [[Category: Arrowsmith, C H]] |
| - | + | [[Category: Bochkarev, A]] | |
| - | + | [[Category: Edwards, A M]] | |
| - | [[Category: | + | [[Category: Keefe, L J]] |
| - | [[Category: | + | [[Category: Landry, R]] |
| - | [[Category: | + | [[Category: Mulichak, A M]] |
| - | [[Category: | + | [[Category: Nedyalkova, L]] |
| - | + | [[Category: Park, H]] | |
| - | + | [[Category: Rabeh, W M]] | |
| - | + | [[Category: Structural genomic]] | |
| + | [[Category: Sundstrom, M]] | ||
| + | [[Category: Tempel, W]] | ||
| + | [[Category: Weigelt, J]] | ||
| + | [[Category: Gtp-binding]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Rragd]] | ||
| + | [[Category: Sgc]] | ||
Current revision
X-ray crystal structure of putative human Ras-related GTP binding D in complex with GMPPNP
| |||||||||||
Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Edwards, A M | Keefe, L J | Landry, R | Mulichak, A M | Nedyalkova, L | Park, H | Rabeh, W M | Structural genomic | Sundstrom, M | Tempel, W | Weigelt, J | Gtp-binding | Protein binding | Rragd | Sgc
