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2qnr

From Proteopedia

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[[Image:2qnr.jpg|left|200px]]
 
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{{Structure
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==Human septin 2 in complex with GDP==
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|PDB= 2qnr |SIZE=350|CAPTION= <scene name='initialview01'>2qnr</scene>, resolution 2.600&Aring;
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<StructureSection load='2qnr' size='340' side='right'caption='[[2qnr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
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<table><tr><td colspan='2'>[[2qnr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNR FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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|GENE= SEPT2, DIFF6, KIAA0158, NEDD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEPT2, DIFF6, KIAA0158, NEDD5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnr OCA], [https://pdbe.org/2qnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qnr RCSB], [https://www.ebi.ac.uk/pdbsum/2qnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qnr ProSAT]</span></td></tr>
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'''Human septin 2 in complex with GDP'''
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SEPT2_HUMAN SEPT2_HUMAN]] Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.<ref>PMID:15774761</ref> <ref>PMID:17803907</ref> <ref>PMID:18209106</ref> <ref>PMID:19145258</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2QNR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNR OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
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Check<jmol>
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[[Category: Single protein]]
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<jmolCheckbox>
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[[Category: Arrowsmith, C H.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qnr_consurf.spt"</scriptWhenChecked>
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[[Category: Bochkarev, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Crombet, L.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Edwards, A M.]]
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</jmolCheckbox>
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[[Category: Kozieradzki, I.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qnr ConSurf].
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[[Category: Landry, R.]]
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<div style="clear:both"></div>
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[[Category: Nedyalkova, L.]]
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== References ==
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[[Category: Park, H.]]
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<references/>
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[[Category: Rabeh, W M.]]
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__TOC__
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[[Category: SGC, Structural Genomics Consortium.]]
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</StructureSection>
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[[Category: Senisterra, G.]]
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[[Category: Human]]
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[[Category: Sundstrom, M.]]
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[[Category: Large Structures]]
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[[Category: Tempel, W.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Vedadi, M.]]
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[[Category: Bochkarev, A]]
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[[Category: Weigelt, J.]]
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[[Category: Crombet, L]]
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[[Category: GDP]]
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[[Category: Edwards, A M]]
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[[Category: UNX]]
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[[Category: Kozieradzki, I]]
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[[Category: cell cycle]]
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[[Category: Landry, R]]
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[[Category: cell division]]
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[[Category: Nedyalkova, L]]
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[[Category: gdp]]
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[[Category: Park, H]]
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[[Category: gtp-binding]]
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[[Category: Rabeh, W M]]
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[[Category: mitosis]]
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[[Category: Structural genomic]]
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[[Category: nucleotide-binding]]
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[[Category: Senisterra, G]]
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[[Category: phosphorylation]]
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[[Category: Sundstrom, M]]
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[[Category: septin]]
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[[Category: Tempel, W]]
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[[Category: sgc]]
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[[Category: Vedadi, M]]
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[[Category: structural genomics consortium]]
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[[Category: Weigelt, J]]
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[[Category: Cell cycle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:45:40 2008''
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[[Category: Cell division]]
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[[Category: Gdp]]
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[[Category: Gtp-binding]]
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[[Category: Mitosis]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Septin]]
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[[Category: Sgc]]

Current revision

Human septin 2 in complex with GDP

PDB ID 2qnr

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