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2qs9

From Proteopedia

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[[Image:2qs9.png|left|200px]]
 
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{{STRUCTURE_2qs9| PDB=2qs9 | SCENE= }}
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==Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978==
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<StructureSection load='2qs9' size='340' side='right'caption='[[2qs9]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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===Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QS9 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBBP9, BOG, RBBP10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[2qs9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS9 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qs9 OCA], [https://pdbe.org/2qs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qs9 RCSB], [https://www.ebi.ac.uk/pdbsum/2qs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qs9 ProSAT], [https://www.topsan.org/Proteins/NESGC/2qs9 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/RBBP9_HUMAN RBBP9_HUMAN]] May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qs/2qs9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qs9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]]
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*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:019004028</ref><references group="xtra"/>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton, T B.]]
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[[Category: Acton, T B]]
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[[Category: Chen, C X.]]
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[[Category: Chen, C X]]
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[[Category: Cunningham, K.]]
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[[Category: Cunningham, K]]
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[[Category: Hunt, J F.]]
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[[Category: Hunt, J F]]
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[[Category: Kuzin, A.]]
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[[Category: Kuzin, A]]
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[[Category: Maglaqui, M.]]
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[[Category: Maglaqui, M]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione, G T]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Owens, L.]]
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[[Category: Owens, L]]
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[[Category: Seetharaman, J.]]
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[[Category: Seetharaman, J]]
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[[Category: Su, M.]]
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[[Category: Su, M]]
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[[Category: Tong, L.]]
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[[Category: Tong, L]]
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[[Category: Vorobiev, S M.]]
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[[Category: Vorobiev, S M]]
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[[Category: Xiao, R.]]
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[[Category: Xiao, R]]
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[[Category: Alternative splicing]]
[[Category: B5t overexpressed gene protein]]
[[Category: B5t overexpressed gene protein]]
[[Category: Bog]]
[[Category: Bog]]
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[[Category: Cytoplasm]]
[[Category: Hr2978]]
[[Category: Hr2978]]
[[Category: Nesg]]
[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
 
[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Rbbp10]]
[[Category: Rbbp10]]
[[Category: Rbbp9]]
[[Category: Rbbp9]]
[[Category: Retinoblastoma-binding protein 10]]
[[Category: Retinoblastoma-binding protein 10]]
[[Category: Retinoblastoma-binding protein 9]]
[[Category: Retinoblastoma-binding protein 9]]
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[[Category: Structural genomic]]
 
[[Category: Structural protein]]
[[Category: Structural protein]]

Current revision

Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978

PDB ID 2qs9

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