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2qs9
From Proteopedia
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| - | [[Image:2qs9.jpg|left|200px]] | ||
| - | + | ==Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978== | |
| - | + | <StructureSection load='2qs9' size='340' side='right'caption='[[2qs9]], [[Resolution|resolution]] 1.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | | | + | <table><tr><td colspan='2'>[[2qs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QS9 FirstGlance]. <br> |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | | | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBBP9, BOG, RBBP10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qs9 OCA], [https://pdbe.org/2qs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qs9 RCSB], [https://www.ebi.ac.uk/pdbsum/2qs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qs9 ProSAT], [https://www.topsan.org/Proteins/NESGC/2qs9 TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/RBBP9_HUMAN RBBP9_HUMAN]] May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. | |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qs/2qs9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qs9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | + | [[Category: Human]] | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Acton, T B]] |
| - | [[Category: Acton, T B | + | [[Category: Chen, C X]] |
| - | [[Category: Chen, C X | + | [[Category: Cunningham, K]] |
| - | [[Category: Cunningham, K | + | [[Category: Hunt, J F]] |
| - | [[Category: Hunt, J F | + | [[Category: Kuzin, A]] |
| - | [[Category: Kuzin, A | + | [[Category: Maglaqui, M]] |
| - | [[Category: Maglaqui, M | + | [[Category: Montelione, G T]] |
| - | [[Category: Montelione, G T | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Owens, L]] |
| - | [[Category: Owens, L | + | [[Category: Seetharaman, J]] |
| - | [[Category: Seetharaman, J | + | [[Category: Su, M]] |
| - | [[Category: Su, M | + | [[Category: Tong, L]] |
| - | [[Category: Tong, L | + | [[Category: Vorobiev, S M]] |
| - | [[Category: Vorobiev, S M | + | [[Category: Xiao, R]] |
| - | [[Category: Xiao, R | + | [[Category: Alternative splicing]] |
| - | [[Category: | + | [[Category: B5t overexpressed gene protein]] |
| - | [[Category: | + | [[Category: Bog]] |
| - | [[Category: | + | [[Category: Cytoplasm]] |
| - | [[Category: | + | [[Category: Hr2978]] |
| - | [[Category: | + | [[Category: Nesg]] |
| - | [[Category: | + | [[Category: Nucleus]] |
| - | [[Category: | + | [[Category: Phosphorylation]] |
| - | [[Category: | + | [[Category: PSI, Protein structure initiative]] |
| - | [[Category: | + | [[Category: Rbbp10]] |
| - | + | [[Category: Rbbp9]] | |
| - | [[Category: | + | [[Category: Retinoblastoma-binding protein 10]] |
| - | [[Category: | + | [[Category: Retinoblastoma-binding protein 9]] |
| - | [[Category: | + | [[Category: Structural protein]] |
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| - | [[Category: | + | |
| - | [[Category: | + | |
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Current revision
Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978
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Categories: Human | Large Structures | Acton, T B | Chen, C X | Cunningham, K | Hunt, J F | Kuzin, A | Maglaqui, M | Montelione, G T | Structural genomic | Owens, L | Seetharaman, J | Su, M | Tong, L | Vorobiev, S M | Xiao, R | Alternative splicing | B5t overexpressed gene protein | Bog | Cytoplasm | Hr2978 | Nesg | Nucleus | Phosphorylation | PSI, Protein structure initiative | Rbbp10 | Rbbp9 | Retinoblastoma-binding protein 10 | Retinoblastoma-binding protein 9 | Structural protein
