Deoxyuridine 5'-triphosphate nucleotidohydrolase
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | + | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' or '''Deoxyuridine triphosphatase''' or '''dUTP pyrophosphatase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. |
Prokaryotic DUTP contains metal ion. <ref>PMID:18837522</ref> | Prokaryotic DUTP contains metal ion. <ref>PMID:18837522</ref> | ||
| Line 18: | Line 18: | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of dUTPase== | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *DUTP | ||
| - | |||
| - | **[[1q5u]] - hDUTP – human<br /> | ||
| - | **[[1dup]], [[1eu5]], [[1euw]] – EcDUTP – ''Escherichia coli''<br /> | ||
| - | **[[1dun]] – EvDUTP – Equine infectious anemia virus<br /> | ||
| - | **[[1mq7]] – MtDUTP – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4gk6]] - DUTP – ''Mycobacterium abscessus''<br /> | ||
| - | **[[1ogl]] – TcDUTP – ''Trypanosoma cruzi''<br /> | ||
| - | **[[2d4l]] - MPmvDUTP residues 83-234 – Mason_Pfizer monkey virus<br /> | ||
| - | **[[2d4m]] - MPmvDUTP residues 83-234 (mutant) <br /> | ||
| - | **[[2okb]], [[2okd]] - VvDUTP – Vaccinia virus<br /> | ||
| - | **[[3hhq]] - yDUTP – yeast<br /> | ||
| - | **[[3lqw]] - DUTP – ''Entamoeba histolytica''<br /> | ||
| - | **[[3mbq]], [[3mdx]] - DUTP – ''Brucella melitensis''<br /> | ||
| - | **[[2xx6]] - BsDUTP – ''Bacillus subtilis''<br /> | ||
| - | **[[3tqz]] - DUTP – ''Coxiella burnetii''<br /> | ||
| - | **[[4lhr]] - DUTP – ''Burkholderia thailandensis''<br /> | ||
| - | **[[3h6x]] - DUTP – ''Streptococcus mutans''<br /> | ||
| - | **[[5myf]] - SaDUTP – ''Staphylococcus aureus''<br /> | ||
| - | **[[5myi]] - SaDUTP (mutant)<br /> | ||
| - | **[[6mai]] - LpDUTP – ''Legionella pneumophila''<br /> | ||
| - | |||
| - | *DUTP binary complexes | ||
| - | |||
| - | **[[4mz5]], [[4mz6]] – hDUTP + importin subunit α-1<br /> | ||
| - | **[[5h4j]] - hDUTP + inhibitor<br /> | ||
| - | **[[1dud]] – EcDUTP + dUDP<br /> | ||
| - | **[[2hrm]] - EcDUTP + dUTP derivative<br /> | ||
| - | **[[1seh]] - EcDUTP + dUMP<br /> | ||
| - | **[[3f4f]] - yDUTP + dUMP<br /> | ||
| - | **[[1dut]] – DUTP + Mg – Feline immunodeficiency virus<br /> | ||
| - | **[[1ogk]] – TcDUTP + dUTP<br /> | ||
| - | **[[1smc]] - MtDUTP + dUTP<br /> | ||
| - | **[[4gcy]] - MtDUTP (mutant) + dUTP<br /> | ||
| - | **[[4a6a]] - MtDUTP (mutant) + dTTP<br /> | ||
| - | **[[1vyq]], [[3t60]], [[3t64]], [[3t6y]], [[3t70]] - PfDUTP + uridine derivative inhibitor – ''Plasmodium falciparum''<br /> | ||
| - | **[[2y8c]] - PfDUTP + trityl ligand<br /> | ||
| - | **[[2bsy]], [[2we0]] - EbvDUTP + dUMP – Epstein-Barr virus<br /> | ||
| - | **[[2we1]], [[2we2]] - EbvDUTP (mutant) + dUMP<br /> | ||
| - | **[[2ol1]] - VvDUTP + dUMP<br /> | ||
| - | **[[2y1t]] - BsDUTP + dUDP<br /> | ||
| - | **[[4ao5]] - BsDUTP + dUMP<br /> | ||
| - | **[[2yb0]] - LmDUTP + dU – ''Leishmania major''<br /> | ||
| - | **[[3tq5]], [[3trl]], [[3trn]], [[3ts6]], [[3tsl]], [[3tta]] - MPmvDUTP catalytic domain (mutant) + dUMP<br /> | ||
| - | **[[4ooq]], [[2pc5]] – AtDUTP + Mg – ''Arabidopsis thaliana''<br /> | ||
| - | **[[3zf0]], [[3zf1]], [[3zf2]], [[3zf3]], [[3zf4]], [[3zf5]], [[3zf6]], [[5cct]], [[5nyz]], [[5nz2]] - SpDUTP (mutant) + dUTP derivative – ''Staphylococcus'' phage 80α<br /> | ||
| - | **[[5cco]] - SpDUTP + dUMP <br /> | ||
| - | **[[4gv8]] - DUTP + dUTP derivative – ''Staphylococcus'' phage 11<br /> | ||
| - | **[[4wrk]] - DUTP (mutant) + dUTP derivative – ''Staphylococcus'' phage φ11<br /> | ||
| - | **[[5myd]] - DUTP + dUTP derivative – ''Staphylococcus'' <br /> | ||
| - | **[[6mao]] - LpDUTP + dUMP <br /> | ||
| - | |||
| - | *DUTP ternary complexes | ||
| - | **[[1duc]] – EvDUPT + Sr + dUTP<br /> | ||
| - | **[[1six]], [[1sjn]], [[2py4]] – MtDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[3h6d]], [[3hza]], [[3i93]] - MtDUTP (mutant) + Mg + dUTP derivative<br /> | ||
| - | **[[3loj]] - MtDUTP (mutant) + Mg + Mn + dUTP derivative<br /> | ||
| - | **[[1rn8]] - EcDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[1rnj]] - EcDUTP (mutant) + Mg + dUTP derivative<br /> | ||
| - | **[[1syl]] - EcDUTP (mutant) + Mg + dUTP<br /> | ||
| - | **[[2hr6]] - EcDUTP + Mn + dUDP<br /> | ||
| - | **[[1slh]] – MtDUTP + Mg + dUDP<br /> | ||
| - | **[[5ect]], [[5edd]] - MtDUTP (mutant) + Mg + dUTP derivative<br /> | ||
| - | **[[1sm8]] – MtDUTP + Cr + dUTP<br /> | ||
| - | **[[1snf]] - MtDUTP + Mg + dUMP<br /> | ||
| - | **[[1w2y]], [[2cic]] - DUTP + Mg + dUTP derivative – ''Campylobacter jejuni''<br /> | ||
| - | **[[5f9k]] - DUTP + Mg + dUTP derivative – slime mold<br /> | ||
| - | **[[2bt1]] - EbvDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[2we3]] - EbvDUTP residues 1-256 + Mg + dUTP<br /> | ||
| - | **[[2d4n]] - MPmvDUTP residues 83-234 (mutant) + Mg + dUTP derivative<br /> | ||
| - | **[[3tp1]] - MPmvDUTP catalytic domain + Mg + dUTP derivative<br /> | ||
| - | **[[3tpw]], [[3tpn]], [[3tps]] - MPmvDUTP catalytic domain (mutant) + Mg + dUTP derivative<br /> | ||
| - | **[[3tpy]], [[3tq3]], [[3tq4]] - MPmvDUTP catalytic domain + Mg + dUMP + dUTP derivative<br /> | ||
| - | **[[2cje]] - LmDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[2yay]] - LmDUTP + Ca + dUTP derivative<br /> | ||
| - | **[[2yaz]] - LmDUTP + Mg + dUMP<br /> | ||
| - | **[[2oke]] - VvDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[2ol0]] - VvDUTP + Mg + dUDP<br /> | ||
| - | **[[3c3i]] - PbcvDUTP (mutant) + Mg + dUDP – Paramecium bursaria chlorella virus<br /> | ||
| - | **[[3c2t]], [[3ca9]] - PbcvDUTP + Mg + dUDP<br /> | ||
| - | **[[2hqu]] - hDUTP + Mg + dUTP derivative <br /> | ||
| - | **[[1q5h]] - hDUTP + Mg + dUDP<br /> | ||
| - | **[[3ehw]] - hDUTP + Mg + dUTP<br /> | ||
| - | **[[3ara]], [[3arn]] - hDUTP + Mg + uracil derivative<br /> | ||
| - | **[[3p48]] - yDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[2xy3]] - BsDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[4oop]] - AtDUTP + Mg + dUTP derivative<br /> | ||
| - | **[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Vertessy BG, Toth J. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res. 2009 Jan 20;42(1):97-106. PMID:18837522 doi:10.1021/ar800114w
- ↑ Moroz OV, Harkiolaki M, Galperin MY, Vagin AA, Gonzalez-Pacanowska D, Wilson KS. The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases. J Mol Biol. 2004 Oct 1;342(5):1583-97. PMID:15364583 doi:10.1016/j.jmb.2004.07.050
