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6cy9

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<StructureSection load='6cy9' size='340' side='right'caption='[[6cy9]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='6cy9' size='340' side='right'caption='[[6cy9]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Group_a_rotaviruses Group a rotaviruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CY9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Group_a_rotaviruses Group a rotaviruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CY9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6auk|6auk]], [[6cya|6cya]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6auk|6auk]], [[6cya|6cya]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NSP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28875 Group A rotaviruses])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NSP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28875 Group A rotaviruses])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cy9 OCA], [http://pdbe.org/6cy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cy9 RCSB], [http://www.ebi.ac.uk/pdbsum/6cy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cy9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cy9 OCA], [https://pdbe.org/6cy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cy9 RCSB], [https://www.ebi.ac.uk/pdbsum/6cy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cy9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A2T3N6_9REOV A2T3N6_9REOV]] Participates in replication and packaging of the viral genome. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities. The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.[HAMAP-Rule:MF_04089][RuleBase:RU364009]
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[[https://www.uniprot.org/uniprot/A2T3N6_9REOV A2T3N6_9REOV]] Participates in replication and packaging of the viral genome. Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities. The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures. The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.[HAMAP-Rule:MF_04089][RuleBase:RU364009]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Hu, L]]
[[Category: Hu, L]]
[[Category: Prasad, B V.V]]
[[Category: Prasad, B V.V]]
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[[Category: Sankaran, B]]
[[Category: Disulfide]]
[[Category: Disulfide]]
[[Category: Nsp2]]
[[Category: Nsp2]]
[[Category: Rotavirus sa11]]
[[Category: Rotavirus sa11]]
[[Category: Viral protein]]
[[Category: Viral protein]]

Revision as of 03:40, 2 July 2021

SA11 Rotavirus NSP2 with disulfide bridge

PDB ID 6cy9

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