DNA methyltransferase 3D structures

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*Methylcytosine DNMT; Domains – RFTS 351-599; ADD 476-611; PWWP 206-355
*Methylcytosine DNMT; Domains – RFTS 351-599; ADD 476-611; PWWP 206-355
-
**[[3epz]] - h-cytosine DNMT 1 replication foci-targeting sequence
+
**[[3epz]] - h-cytosine DNMT 1 RFTS domain<br />
-
**[[4yoc]] - h-cytosine DNMT 1 residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br />
+
**[[1g55]] - h-cytosine DNMT 2 (mutant) <br />
-
**[[4z97]], [[4z96]] - h-cytosine DNMT 1 residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br />
+
-
**[[5ydr]] - h-cytosine DNMT 1 RFTS domain residues 351-599 + ubiquitin<br />
+
-
**[[5wvo]] - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1<br />
+
-
**[[4wxx]] - h-cytosine DNMT 1 residues 351-1600 + SAH<br />
+
-
**[[1g55]] - h-cytosine DNMT 2 (mutant)<br />
+
**[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br />
**[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br />
**[[3a1a]] - h-cytosine DNMT 3A ADD domain<br />
**[[3a1a]] - h-cytosine DNMT 3A ADD domain<br />
-
**[[3a1b]], [[4qbq]] - h-cytosine DNMT 3A ADD domain + histone H3<br />
 
-
**[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br />
 
-
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
 
-
**[[6pa7]] - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM<br />
 
-
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
 
-
**[[6w89]], [[6w8b]], [[6w8d]], [[6w6j]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
 
-
**[[6f57]], [[5yx2]], [[6brr]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
 
**[[3flg]] - h-cytosine DNMT 3B PWWP domain<br />
**[[3flg]] - h-cytosine DNMT 3B PWWP domain<br />
-
**[[6r3e]] - h-cytosine DNMT 3B PWWP domain + inhibitor<br />
 
**[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br />
**[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br />
-
**[[5nvo]] - h-cytosine DNMT 3B PWWP domain + choline<br />
+
**[[3av4]], [[1khc]] - m-cytosine DNMT residues 291-1620 – mouse<br />
-
**[[5nv7]], [[5nv2]], [[5nv0]], [[5nrv]], [[5nrs]], [[5nrr]], [[5nr3]] - h-cytosine DNMT 3B PWWP domain + inhibitor<br />
+
-
**[[5ciu]] - h-cytosine DNMT 3B residues 206-355 + histone H3.2<br />
+
-
**[[6u8p]], [[6u8v]], [[6u8w]], [[6u8x]], [[6u90]], [[6u91]] - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
+
-
**[[3swr]] - h-cytosine DNMT + sinefungin<br />
+
-
**[[6pzv]] - cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine<br />
+
-
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br />
+
**[[5wy1]] - m-cytosine DNMT (mutant) <br />
**[[5wy1]] - m-cytosine DNMT (mutant) <br />
**[[5guv]], [[5gut]] - m-cytosine DNMT residues 731-1600 (mutant) <br />
**[[5guv]], [[5gut]] - m-cytosine DNMT residues 731-1600 (mutant) <br />
-
**[[6w8v]], [[6w8w]] - m-cytosine DNMT1 residues 731-1600 + SAH + CMP derivative<br />
+
**[[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris''<br />
-
**[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT residues 650-1602 + DNA
+
**[[1svu]] - Hh-cytosine DNMT (mutant) - ''Haemophilus haemolyticus''<br />
-
+
**[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''<br />
-
**[[3av5]] - m-cytosine DNMT + SAH residues 291-1620
+
-
**[[3av6]] - m-cytosine DNMT + SAM residues 291-1620
+
*Methylcytosine DNMT complex with DNA
-
**[[4fsx]] – c-cytosine DNMT + SAH – corn<br />
+
**[[6pa7]] - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM<br />
-
**[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br />
+
**[[6w89]], [[6w8b]], [[6w8d]], [[6w6j]] - h-cytosine DNMT 3A residues 628-912 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
-
**[[6fdf]] - cytosine DNMT2 + SAH – fission yeast<br/>
+
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br />
-
**[[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris''<br />
+
**[[6brr]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br />
-
**[[3qv2]] - cytosine DNMT + SAH – ''Entamoeba histolytica''<br />
+
**[[6w8b]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH<br />
-
**[[2uyc]], [[2uyh]], [[2uz4]], [[1fjx]] – Hh-cytosine DNMT (mutant) + DNA + SAH - ''Haemophilus haemolyticus''<br />
+
**[[6kda]], [[6kdb]], [[6kdl]] - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + DNA + SAH <br />
-
**[[2c7o]], [[2c7p]], [[2c7q]], [[2c7r]], [[3pta]] – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine<br />
+
**[[6u8p]], [[6u8v]], [[6u8x]] - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
-
**[[1hmy]] – Hh-cytosine Haeiii DNMT + SAM
+
**[[6u8w]], [[6u90]], [[6u91]] - h-cytosine DNMT 3B residues 563-853 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
 +
**[[6w8v]], [[6w8w]] - m-cytosine DNMT1 residues 731-1600 + SAH + DNA<br />
 +
**[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT residues 650-1602 + DNA<br />
 +
**[[2uyc]], [[2uyh]], [[2uz4]], [[1fjx]] – Hh-cytosine DNMT (mutant) + DNA + SAH<br />
 +
**[[2c7o]], [[2c7p]], [[2c7q]], [[2c7r]], [[3pta]], [[4da4]] – Hh-cytosine DNMT + DNA + SAH<br />
 +
**[[1m0e]] - Hh-cytosine DNMT (mutant) + DNA + inhibitor<br />
 +
**[[2i9k]] – Hh-cytosine DNMT (mutant) + DNA<br />
 +
**[[2hr1]] - Hh-cytosine DNMT + DNA + ADOHCY<br />
 +
**[[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY<br />
-
**[[1m0e]] - Hh-cytosine DNMT (mutant) + DNA + inhibitor
+
*Methylcytosine DNMT complex with protein
-
**[[2i9k]] - Hh-cytosine DNMT (mutant) + DNA
+
**[[4yoc]] - h-cytosine DNMT 1 residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br />
 +
**[[4z97]], [[4z96]] - h-cytosine DNMT 1 residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br />
 +
**[[5ydr]] - h-cytosine DNMT 1 RFTS domain + ubiquitin<br />
 +
**[[5wvo]] - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1<br />
 +
**[[3a1b]], [[4qbq]] - h-cytosine DNMT 3A ADD domain + histone H3
 +
**[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br />
 +
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + histone 3.3 peptide + SAH<br />
 +
**[[5ciu]] - h-cytosine DNMT 3B residues 206-355 + histone H3.2<br />
 +
**[[6pzv]] – b-cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine<br />
 +
**[[7lmk]], [[7lmm]] – b-cytosine DNMT 1 BAH1 domain + histone H4 <br />
 +
**[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide – corn<br />
-
**[[2hr1]] - Hh-cytosine DNMT + DNA + ADOHCY
+
*Methylcytosine DNMT complex with small molecule
-
**[[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY
+
**[[4wxx]] - h-cytosine DNMT 1 residues 351-1600 + SAH<br />
-
 
+
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + SAH<br />
-
**[[1svu]] - Hh-cytosine DNMT (mutant)<br />
+
**[[5nvo]] - h-cytosine DNMT 3B PWWP domain + choline<br />
-
**[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''<br/>
+
**[[5nv7]], [[5nv2]], [[5nv0]], [[5nrv]], [[5nrs]], [[5nrr]], [[5nr3]], [[6r3e]] - h-cytosine DNMT 3B PWWP domain + inhibitor<br />
 +
**[[6kdp]] - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + SAH <br />
 +
**[[6kdt]] - h-cytosine DNMT 3B residues 563-853 (mutant) + h-cytosine DNMT 3L residues 178-386 + SAH <br />
 +
**[[3swr]] - h-cytosine DNMT + sinefungin<br />
 +
**[[6w8v]], [[6w8w]] - m-cytosine DNMT1 residues 731-1600 + SAH + CMP derivative<br />
 +
**[[3av5]] - m-cytosine DNMT residues 291-1620 + SAH<br />
 +
**[[3av6]] - m-cytosine DNMT residues 650-1620 + SAM<br />
 +
**[[4fsx]] – c-cytosine DNMT + SAH <br />
 +
**[[3qv2]] - cytosine DNMT + SAH – ''Entamoeba histolytica<''br />
 +
**[[1hmy]] – HhHaeiii DNMT + SAM<br />
*Methyladenine DNMT
*Methyladenine DNMT

Revision as of 10:10, 4 July 2021

3D Structures of DNA methyltransferase

Updated on 04-July-2021

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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