Thioether protein crosslinks
From Proteopedia
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Thioether bonds between '''cysteine and tyrosine''' have been well studied in cysteine dioxygenases<ref>PMID:25390690</ref>. Thioether bonds between '''cysteine and the vinyl groups of hemes''' are common. Diverse other '''ligands''' are bonded to protein via cysteine thioether linkages. | Thioether bonds between '''cysteine and tyrosine''' have been well studied in cysteine dioxygenases<ref>PMID:25390690</ref>. Thioether bonds between '''cysteine and the vinyl groups of hemes''' are common. Diverse other '''ligands''' are bonded to protein via cysteine thioether linkages. | ||
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| + | An accurate estimate of the frequency of thioethers in the [[PDB]] may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character [[PDB codes]]. | ||
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| + | ==Examples== | ||
| + | ===Cys-Tyr=== | ||
| + | [[6e87]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 19:34, 4 July 2021
Thioether bonds between cysteine and tyrosine have been well studied in cysteine dioxygenases[1]. Thioether bonds between cysteine and the vinyl groups of hemes are common. Diverse other ligands are bonded to protein via cysteine thioether linkages.
An accurate estimate of the frequency of thioethers in the PDB may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character PDB codes.
Examples
Cys-Tyr
References
- ↑ Davies CG, Fellner M, Tchesnokov EP, Wilbanks SM, Jameson GN. The Cys-Tyr Crosslink of Cysteine Dioxygenase changes the Optimum pH of Reaction without Structural Change. Biochemistry. 2014 Nov 12. PMID:25390690 doi:http://dx.doi.org/10.1021/bi501277a
