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1eso

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[[Image:1eso.gif|left|200px]]
[[Image:1eso.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1eso |SIZE=350|CAPTION= <scene name='initialview01'>1eso</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1eso", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CUL:Cu+Ligands'>CUL</scene> and <scene name='pdbsite=ZNL:Zn+Ligands'>ZNL</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1eso| PDB=1eso | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eso OCA], [http://www.ebi.ac.uk/pdbsum/1eso PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1eso RCSB]</span>
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}}
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'''MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI'''
'''MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI'''
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[[Category: Pesce, A.]]
[[Category: Pesce, A.]]
[[Category: Rotilio, G.]]
[[Category: Rotilio, G.]]
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[[Category: copper enzyme]]
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[[Category: Copper enzyme]]
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[[Category: cu,zn superoxide dismutase]]
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[[Category: Cu,zn superoxide dismutase]]
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[[Category: enzyme evolution]]
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[[Category: Enzyme evolution]]
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[[Category: monomeric superoxide dismutase]]
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[[Category: Monomeric superoxide dismutase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: x-ray crystal structure]]
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[[Category: X-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:28:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:08:49 2008''
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Revision as of 12:28, 2 May 2008

Image:1eso.gif

Template:STRUCTURE 1eso

MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI


Overview

The first three-dimensional structure of a functional monomeric Cu, Zn superoxide dismutase (from Escherichia coli, E_SOD) is reported at 2.0 A resolution (R-factor=16.8%). Compared to the homologous eukaryotic enzymes, E_SOD displays a perturbed antiparallel beta-barrel structure. The most striking structural features observed include extended amino acid insertions in the surface 1, 2-loop and S-S subloop, modification of the disulfide bridge connection, and loss of functional electrostatic residues, suggesting a modified control of substrate steering toward the catalytic center. The active site Cu2+ displays a distorted coordination sphere due to an unusually long bond to the metal-bridging residue His61. Inspection of the crystal packing does not show regions of extended contact indicative of a dimeric assembly. The molecular surface region involved in subunit dimerization in eukaryotic superoxide dismutases is structurally altered in E_SOD and displays a net polar nature.

About this Structure

1ESO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Unique structural features of the monomeric Cu,Zn superoxide dismutase from Escherichia coli, revealed by X-ray crystallography., Pesce A, Capasso C, Battistoni A, Folcarelli S, Rotilio G, Desideri A, Bolognesi M, J Mol Biol. 1997 Dec 5;274(3):408-20. PMID:9405149 Page seeded by OCA on Fri May 2 15:28:27 2008

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