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2ror
From Proteopedia
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| - | [[Image:2ror.png|left|200px]] | ||
| - | + | ==Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76== | |
| - | + | <StructureSection load='2ror' size='340' side='right'caption='[[2ror]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ror]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |
| - | == | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VAV1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[2ror]] is a 2 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ror FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ror OCA], [https://pdbe.org/2ror PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ror RCSB], [https://www.ebi.ac.uk/pdbsum/2ror PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ror ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Kasai, T | + | == Function == |
| - | [[Category: Kigawa, T | + | [[https://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. [[https://www.uniprot.org/uniprot/LCP2_HUMAN LCP2_HUMAN]] Involved in T-cell antigen receptor mediated signaling. |
| - | [[Category: Koshiba, S | + | == Evolutionary Conservation == |
| - | [[Category: | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: Tanaka, M | + | Check<jmol> |
| - | [[Category: Yokoyama, S | + | <jmolCheckbox> |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2ror_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ror ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kasai, T]] | ||
| + | [[Category: Kigawa, T]] | ||
| + | [[Category: Koshiba, S]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Tanaka, M]] | ||
| + | [[Category: Yokoyama, S]] | ||
[[Category: Guanine-nucleotide releasing factor]] | [[Category: Guanine-nucleotide releasing factor]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
| Line 25: | Line 40: | ||
[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sh2 domain]] | [[Category: Sh2 domain]] | ||
| Line 31: | Line 45: | ||
[[Category: Signal transduction]] | [[Category: Signal transduction]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: | + | [[Category: Zinc]] |
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Current revision
Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76
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Categories: Human | Large Structures | Kasai, T | Kigawa, T | Koshiba, S | Structural genomic | Tanaka, M | Yokoyama, S | Guanine-nucleotide releasing factor | Metal-binding | National project on protein structural and functional analyse | Nppsfa | Phorbol-ester binding | Phosphoprotein | Phosphorylated peptide recognition | Phosphotyrosine binding domain | Protein-peptide complex | Proto-oncogene | Rsgi | Sh2 domain | Sh3 domain | Signal transduction | Signaling protein | Zinc | Zinc-finger
