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2v9b

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[[Image:2v9b.jpg|left|200px]]
 
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==X-ray structure of viscotoxin B2 from Viscum album==
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The line below this paragraph, containing "STRUCTURE_2v9b", creates the "Structure Box" on the page.
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<StructureSection load='2v9b' size='340' side='right'caption='[[2v9b]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v9b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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-->
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jmp|1jmp]], [[1orl|1orl]]</div></td></tr>
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{{STRUCTURE_2v9b| PDB=2v9b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9b OCA], [https://pdbe.org/2v9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9b RCSB], [https://www.ebi.ac.uk/pdbsum/2v9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/THNB_VISAL THNB_VISAL]] Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.[REFERENCE:3]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v9b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystals of the cytotoxic thionin proteins viscotoxins A1 and B2 extracted from mistletoe diffracted to high resolution (1.25 and 1.05 A, respectively) and are excellent candidates for testing crystallographic methods. Ab initio direct methods were only successful in solving the viscotoxin B2 structure, which with 861 unique non-H atoms is one of the largest unknown structures without an atom heavier than sulfur to be solved in this way, but sulfur-SAD phasing provided a convincing solution for viscotoxin A1. Both proteins form dimers in the crystal and viscotoxin B2 (net charge +4 per monomer), but not viscotoxin A1 (net charge +6), is coordinated by sulfate or phosphate anions. The viscotoxin A1 crystal has a higher solvent content than the viscotoxin B2 crystal (49% as opposed to 28%) with solvent channels along the crystallographic 4(3) axes.
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'''X-RAY STRUCTURE OF VISCOTOXIN B2 FROM VISCUM ALBUM'''
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Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone.,Pal A, Debreczeni JE, Sevvana M, Gruene T, Kahle B, Zeeck A, Sheldrick GM Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-92. Epub 2008, Aug 13. PMID:18703848<ref>PMID:18703848</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2V9B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9B OCA].
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<div class="pdbe-citations 2v9b" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: Debreczeni, J E.]]
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[[Category: Debreczeni, J E]]
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[[Category: Kahle, B.]]
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[[Category: Kahle, B]]
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[[Category: Pal, A.]]
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[[Category: Pal, A]]
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[[Category: Sheldrick, G M.]]
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[[Category: Sheldrick, G M]]
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[[Category: Zeeck, A.]]
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[[Category: Zeeck, A]]
[[Category: Plant defense]]
[[Category: Plant defense]]
[[Category: Plant toxin]]
[[Category: Plant toxin]]
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[[Category: Thionin]]
[[Category: Thionin]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:04:21 2008''
 

Current revision

X-ray structure of viscotoxin B2 from Viscum album

PDB ID 2v9b

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