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2vcp

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==Crystal structure of N-Wasp VC domain in complex with skeletal actin==
==Crystal structure of N-Wasp VC domain in complex with skeletal actin==
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<StructureSection load='2vcp' size='340' side='right' caption='[[2vcp]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='2vcp' size='340' side='right'caption='[[2vcp]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vcp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vcp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lcu|1lcu]], [[2a42|2a42]], [[2aso|2aso]], [[1ijj|1ijj]], [[1wua|1wua]], [[1o1a|1o1a]], [[1m8q|1m8q]], [[1o18|1o18]], [[1uy5|1uy5]], [[1rfq|1rfq]], [[2d1k|2d1k]], [[1ma9|1ma9]], [[1rdw|1rdw]], [[1o1b|1o1b]], [[1o1d|1o1d]], [[2a40|2a40]], [[2a5x|2a5x]], [[1qz5|1qz5]], [[1nwk|1nwk]], [[1j6z|1j6z]], [[1sqk|1sqk]], [[1atn|1atn]], [[1s22|1s22]], [[1t44|1t44]], [[2ff3|2ff3]], [[1eqy|1eqy]], [[1mvw|1mvw]], [[2ff6|2ff6]], [[2fxu|2fxu]], [[1o1f|1o1f]], [[2asp|2asp]], [[1kxp|1kxp]], [[1rgi|1rgi]], [[2v39|2v39]], [[1o19|1o19]], [[1y64|1y64]], [[1alm|1alm]], [[1o1e|1o1e]], [[1p8z|1p8z]], [[1esv|1esv]], [[1o1c|1o1c]], [[1h1v|1h1v]], [[1o1g|1o1g]], [[2a3z|2a3z]], [[1lot|1lot]], [[2asm|2asm]], [[2a41|2a41]], [[1qz6|1qz6]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lcu|1lcu]], [[2a42|2a42]], [[2aso|2aso]], [[1ijj|1ijj]], [[1wua|1wua]], [[1o1a|1o1a]], [[1m8q|1m8q]], [[1o18|1o18]], [[1uy5|1uy5]], [[1rfq|1rfq]], [[2d1k|2d1k]], [[1ma9|1ma9]], [[1rdw|1rdw]], [[1o1b|1o1b]], [[1o1d|1o1d]], [[2a40|2a40]], [[2a5x|2a5x]], [[1qz5|1qz5]], [[1nwk|1nwk]], [[1j6z|1j6z]], [[1sqk|1sqk]], [[1atn|1atn]], [[1s22|1s22]], [[1t44|1t44]], [[2ff3|2ff3]], [[1eqy|1eqy]], [[1mvw|1mvw]], [[2ff6|2ff6]], [[2fxu|2fxu]], [[1o1f|1o1f]], [[2asp|2asp]], [[1kxp|1kxp]], [[1rgi|1rgi]], [[2v39|2v39]], [[1o19|1o19]], [[1y64|1y64]], [[1alm|1alm]], [[1o1e|1o1e]], [[1p8z|1p8z]], [[1esv|1esv]], [[1o1c|1o1c]], [[1h1v|1h1v]], [[1o1g|1o1g]], [[2a3z|2a3z]], [[1lot|1lot]], [[2asm|2asm]], [[2a41|2a41]], [[1qz6|1qz6]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcp OCA], [http://pdbe.org/2vcp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcp RCSB], [http://www.ebi.ac.uk/pdbsum/2vcp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcp OCA], [https://pdbe.org/2vcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcp RCSB], [https://www.ebi.ac.uk/pdbsum/2vcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/WASL_HUMAN WASL_HUMAN]] Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.<ref>PMID:19366662</ref>
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[[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[https://www.uniprot.org/uniprot/WASL_HUMAN WASL_HUMAN]] Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.<ref>PMID:19366662</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Actin|Actin]]
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*[[Actin 3D structures|Actin 3D structures]]
*[[Wiskott-Aldrich syndrome protein|Wiskott-Aldrich syndrome protein]]
*[[Wiskott-Aldrich syndrome protein|Wiskott-Aldrich syndrome protein]]
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Carlier, M F]]
[[Category: Carlier, M F]]

Revision as of 10:44, 7 July 2021

Crystal structure of N-Wasp VC domain in complex with skeletal actin

PDB ID 2vcp

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