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2vld

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==CRYSTAL STRUCTURE OF A REPAIR ENDONUCLEASE FROM PYROCOCCUS ABYSSI==
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<StructureSection load='2vld' size='340' side='right' caption='[[2vld]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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==crystal structure of a repair endonuclease from Pyrococcus abyssi==
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<StructureSection load='2vld' size='340' side='right'caption='[[2vld]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLD OCA]. <br>
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<table><tr><td colspan='2'>[[2vld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"pyrococcus_abyssi"_erauso_et_al._1993 "pyrococcus abyssi" erauso et al. 1993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VLD FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nucS, PYRAB01260, PAB2263 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29292 "Pyrococcus abyssi" Erauso et al. 1993])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vld RCSB], [http://www.ebi.ac.uk/pdbsum/2vld PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vld OCA], [https://pdbe.org/2vld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vld RCSB], [https://www.ebi.ac.uk/pdbsum/2vld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vld ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/NUCS_PYRAB NUCS_PYRAB]] Cleaves both 3' and 5' ssDNA extremities of branched DNA structures. Binds to ssDNA.[HAMAP-Rule:MF_00722]<ref>PMID:19609302</ref> <ref>PMID:22431731</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vld_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vld_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vld ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Structure and function of a novel endonuclease acting on branched DNA substrates.,Ren B, Kuhn J, Meslet-Cladiere L, Briffotaux J, Norais C, Lavigne R, Flament D, Ladenstein R, Myllykallio H EMBO J. 2009 Aug 19;28(16):2479-89. Epub 2009 Jul 16. PMID:19609302<ref>PMID:19609302</ref>
Structure and function of a novel endonuclease acting on branched DNA substrates.,Ren B, Kuhn J, Meslet-Cladiere L, Briffotaux J, Norais C, Lavigne R, Flament D, Ladenstein R, Myllykallio H EMBO J. 2009 Aug 19;28(16):2479-89. Epub 2009 Jul 16. PMID:19609302<ref>PMID:19609302</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vld" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyrococcus abyssi]]
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[[Category: Pyrococcus abyssi erauso et al. 1993]]
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[[Category: Briffotaux, J.]]
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[[Category: Large Structures]]
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[[Category: Flament, D.]]
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[[Category: Briffotaux, J]]
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[[Category: Kuhn, J.]]
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[[Category: Flament, D]]
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[[Category: Ladenstein, R.]]
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[[Category: Kuhn, J]]
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[[Category: Lavigne, R.]]
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[[Category: Ladenstein, R]]
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[[Category: Meslet-Cladiere, L.]]
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[[Category: Lavigne, R]]
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[[Category: Myllykallio, H.]]
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[[Category: Meslet-Cladiere, L]]
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[[Category: Norais, C.]]
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[[Category: Myllykallio, H]]
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[[Category: Ren, B.]]
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[[Category: Norais, C]]
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[[Category: Ren, B]]
[[Category: Endonuclease]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Current revision

crystal structure of a repair endonuclease from Pyrococcus abyssi

PDB ID 2vld

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