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1ci6

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<StructureSection load='1ci6' size='340' side='right'caption='[[1ci6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='1ci6' size='340' side='right'caption='[[1ci6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ci6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CI6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ci6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci6 OCA], [http://pdbe.org/1ci6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ci6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci6 OCA], [https://pdbe.org/1ci6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATF4_HUMAN ATF4_HUMAN]] Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA.<ref>PMID:15775988</ref> <ref>PMID:16682973</ref> <ref>PMID:18940792</ref> [[http://www.uniprot.org/uniprot/CEBPB_MOUSE CEBPB_MOUSE]] Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:19641492</ref>
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[[https://www.uniprot.org/uniprot/ATF4_HUMAN ATF4_HUMAN]] Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA.<ref>PMID:15775988</ref> <ref>PMID:16682973</ref> <ref>PMID:18940792</ref> [[https://www.uniprot.org/uniprot/CEBPB_MOUSE CEBPB_MOUSE]] Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:19641492</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 10:37, 14 July 2021

TRANSCRIPTION FACTOR ATF4-C/EBP BETA BZIP HETERODIMER

PDB ID 1ci6

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