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1f16

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<StructureSection load='1f16' size='340' side='right'caption='[[1f16]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1f16' size='340' side='right'caption='[[1f16]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1f16]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F16 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1f16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F16 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f16 OCA], [http://pdbe.org/1f16 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f16 RCSB], [http://www.ebi.ac.uk/pdbsum/1f16 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f16 ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f16 OCA], [https://pdbe.org/1f16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f16 RCSB], [https://www.ebi.ac.uk/pdbsum/1f16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f16 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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[[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 09:45, 21 July 2021

SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX

PDB ID 1f16

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